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Vol. 11, No. 2, 2013
Issue release date: November 2012
Section title: Paper
Neurodegener Dis 2013;11:102–111
(DOI:10.1159/000341999)

Dissociating the Cognitive Effects of Levodopa versus Dopamine Agonists in a Neurocomputational Model of Learning in Parkinson’s Disease

Moustafa A.A.a, b · Herzallah M.M.b, c · Gluck M.A.b
aMarcs Institute for Brain and Behaviour and Foundational Processes of Behaviour, School of Social Sciences and Psychology, University of Western Sydney, Sydney, N.S.W., Australia; bCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, N.J., USA; cAl-Quds Cognitive Neuroscience Laboratories, Al Quds University-Abu Dis, Abu Dis, Palestinian Territories

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/31/2012
Issue release date: November 2012

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Background/Aims: Levodopa and dopamine agonists have different effects on the motor, cognitive, and psychiatric aspects of Parkinson’s disease (PD). Methods: Using a computational model of basal ganglia (BG) and prefrontal cortex (PFC) dopamine, we provide a theoretical synthesis of the dissociable effects of these dopaminergic medications on brain and cognition. Our model incorporates the findings that levodopa is converted by dopamine cells into dopamine, and thus activates prefrontal and striatal D1 and D2 dopamine receptors, whereas antiparkinsonian dopamine agonists directly stimulate D2 receptors in the BG and PFC (although some have weak affinity to D1 receptors). Results: In agreement with prior neuropsychological studies, our model explains how levodopa enhances, but dopamine agonists impair or have no effect on, stimulus-response learning and working memory. Conclusion: Our model explains how levodopa and dopamine agonists have differential effects on motor and cognitive processes in PD.

© 2012 S. Karger AG, Basel


  

Author Contacts

Ahmed A. Moustafa
School of Social Sciences and Psychology
Locked Bag 1797
Penrith, NSW 2751 (Australia)
E-Mail a.moustafa@uws.edu.au

  

Article Information

Published online: November 1, 2012
Number of Print Pages : 10
Number of Figures : 3, Number of Tables : 4, Number of References : 80

  

Publication Details

Neurodegenerative Diseases

Vol. 11, No. 2, Year 2013 (Cover Date: November 2012)

Journal Editor: Nitsch R.M. (Zürich), Hock C. (Zürich)
ISSN: 1660-2854 (Print), eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/31/2012
Issue release date: November 2012

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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