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Table of Contents
Vol. 123, No. 2, 2012
Issue release date: November 2012
Section title: Original Research
Cardiology 2012;123:125–132
(DOI:10.1159/000342050)

Intracoronary Monocyte Chemoattractant Protein 1 and Vascular Endothelial Growth Factor Levels Are Associated with Necrotic Core, Calcium and Fibrous Tissue Atherosclerotic Plaque Components: An Intracoronary Ultrasound Radiofrequency Study

Fuchs S.a, d · Lavi I.e · Tzang O.e · Bessler H.b, d · Brosh D.c · Bental T.c · Dvir D.c · Einav S.e · Kornowski R.c, d
aDepartment of Medicine B, Rabin Medical Center, bImmunology and Hematology Research Laboratory, and cDepartment of Cardiology, Rabin Medical Center, Interventional Cardiology Institute, Petach Tikva, and dThe Sackler School of Medicine and eDepartment of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: March 22, 2012
Accepted: June 18, 2012
Published online: October 20, 2012
Issue release date: November 2012

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Aims: To investigate the relationship between various serum biomarkers and coronary atherosclerotic plaque composition obtained by intravascular ultrasound virtual histology (IVUS-VH). Methods: Using ELISA, we measured the serum levels of CD40 ligand, C-reactive protein, monocyte chemoattractant protein 1 (MCP-1), metalloproteinase 9, P-selectin and vascular endothelial growth factor (VEGF) in 40 patients with manifested coronary artery disease. Results: Correlation analysis between biomarkers levels, IVUS grayscale parameters and VH-defined necrotic core (NC), calcium, fibrous and fibrofatty components was performed. MCP-1 and VEGF levels correlated with the severity of area stenosis (r = 0.35, p = 0.03 and r = 0.38, p = 0.017, respectively) and inversely correlated with the remodeling index (r = –0.35, p = 0.03 and r = 0.35, p = 0.02, respectively). Higher levels of MCP-1 were associated with increased calcium (r = 0.47, p = 0.004), NC (r = 0.38, p = 0.02) and less fibrous tissue components (r = –0.34, p = 0.03), whereas VEGF had an inverse correlation with both calcium components (r = –0.37, p = 0.02) and NC (r = –0.34, p = 0.036) but was strongly associated with increased fibrous components (r = 0.47, p = 0.003). No significant correlation was noted for any of the other biomarkers. Conclusions: MCP-1 and VEGF serum levels in patients with ischemic heart disease are correlated with coronary artery plaque burden and composition.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: March 22, 2012
Accepted: June 18, 2012
Published online: October 20, 2012
Issue release date: November 2012

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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