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Intracoronary Monocyte Chemoattractant Protein 1 and Vascular Endothelial Growth Factor Levels Are Associated with Necrotic Core, Calcium and Fibrous Tissue Atherosclerotic Plaque Components: An Intracoronary Ultrasound Radiofrequency StudyFuchs S.a, d · Lavi I.e · Tzang O.e · Bessler H.b, d · Brosh D.c · Bental T.c · Dvir D.c · Einav S.e · Kornowski R.c, d
aDepartment of Medicine B, Rabin Medical Center, bImmunology and Hematology Research Laboratory, and cDepartment of Cardiology, Rabin Medical Center, Interventional Cardiology Institute, Petach Tikva, and dThe Sackler School of Medicine and eDepartment of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel
Aims: To investigate the relationship between various serum biomarkers and coronary atherosclerotic plaque composition obtained by intravascular ultrasound virtual histology (IVUS-VH). Methods: Using ELISA, we measured the serum levels of CD40 ligand, C-reactive protein, monocyte chemoattractant protein 1 (MCP-1), metalloproteinase 9, P-selectin and vascular endothelial growth factor (VEGF) in 40 patients with manifested coronary artery disease. Results: Correlation analysis between biomarkers levels, IVUS grayscale parameters and VH-defined necrotic core (NC), calcium, fibrous and fibrofatty components was performed. MCP-1 and VEGF levels correlated with the severity of area stenosis (r = 0.35, p = 0.03 and r = 0.38, p = 0.017, respectively) and inversely correlated with the remodeling index (r = –0.35, p = 0.03 and r = 0.35, p = 0.02, respectively). Higher levels of MCP-1 were associated with increased calcium (r = 0.47, p = 0.004), NC (r = 0.38, p = 0.02) and less fibrous tissue components (r = –0.34, p = 0.03), whereas VEGF had an inverse correlation with both calcium components (r = –0.37, p = 0.02) and NC (r = –0.34, p = 0.036) but was strongly associated with increased fibrous components (r = 0.47, p = 0.003). No significant correlation was noted for any of the other biomarkers. Conclusions: MCP-1 and VEGF serum levels in patients with ischemic heart disease are correlated with coronary artery plaque burden and composition.
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