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Vol. 123, No. 2, 2012
Issue release date: November 2012
Section title: Original Research
Cardiology 2012;123:84–90
(DOI:10.1159/000342055)

Glycated Albumin Is Superior to Hemoglobin A1c for Evaluating the Presence and Severity of Coronary Artery Disease in Type 2 Diabetic Patients

Shen Y. · Pu L.J. · Lu L. · Zhang Q. · Zhang R.Y. · Shen W.F.
aDepartment of Cardiology, Rui Jin Hospital, and bInstitute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/3/2012 9:09:42 AM
Accepted: 7/5/2012
Published online: 9/25/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: This study aimed to compare the value of serum glycated albumin (GA) level versus glycated hemoglobin A1c (HbA1c) for evaluating the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Methods: Serum GA and blood HbA1c levels were measured in 829 consecutive T2DM patients with or without angiographically documented significant CAD (≥70% diameter stenosis). Results: Serum GA levels were higher in diabetic patients with significant CAD than in those without (20.57 ± 4.23 vs. 19.00 ± 4.48%; p < 0.001), but HbA1c was similar in the two groups (7.74 ± 1.34 vs. 7.51 ± 1.37% p > 0.05). Compared to HbA1c, GA correlated more closely with the sum of significant stenotic lesions (r = 0.275, p < 0.001 and r = 0.092, p = 0.019) and the extent index (r = 0.375, p < 0.001 and r = 0.091, p = 0.019). The area under the curve of GA was larger than that of HbA1c for detecting the presence of significant CAD (0.637 vs. 0.568; p = 0.046) and 3-vessel disease (0.620 vs. 0.536; p = 0.039). GA, but not HbA1c, was independently associated with significant CAD. Conclusions: Serum GA level is a better indicator than HbA1c for evaluating the presence and severity of CAD and predicting major adverse cardiac events in patients with T2DM.


  

Author Contacts

Wei Feng Shen, MD, PhD
Department of Cardiology, Rui Jin Hospital
197 Rui Jin Road II
Shanghai 200025 (PR China)
E-Mail rjshenweifeng@yahoo.com.cn

  

Article Information

Received: May 3, 2012
Accepted after revision: July 5, 2012
Published online: September 25, 2012
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 1, Number of References : 31

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 123, No. 2, Year 2012 (Cover Date: November 2012)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008-6312 (Print), eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 5/3/2012 9:09:42 AM
Accepted: 7/5/2012
Published online: 9/25/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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