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Table of Contents
Vol. 84, No. 2, 2013
Issue release date: December 2012
Section title: Clinical Study
Oncology 2013;84:67–74
(DOI:10.1159/000342087)

Adherence with Oral Oncologic Treatment in Cancer Patients: Interest of an Adherence Score of All Dosing Errors

Thivat E.a,e,f · Van Praagh I.b,e–g · Belliere A.c,e,g · Mouret-Reynier M.A.b,e–g · Kwiatkowski F.a,e,f · Durando X.a,b,e,g,h · Mahammedi H.b,e,g · Dillies A.F.b,e,g · Chollet P.a,b,e,g,h · Chevrier R.d, e
aDivision of Clinical Research and Departments of bOncology, cRadiation Oncology and dPharmacy, Centre Jean Perrin, eCentre d’Investigation Clinique UMR 501, fEA 4677 ERTICA, Université d’Auvergne, gUniversity Clermont 1, UFR Médecine, and hUMR 990 INSERM/UdA, Clermont-Ferrand, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: April 12, 2012
Accepted: July 13, 2012
Published online: October 31, 2012
Issue release date: December 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Purpose: Patient nonadherence to oral antineoplastic therapy is a well-recognized barrier to effective treatment. In order to identify patients who may need additional support to become adherent, it is important to have a useful tool that takes into account all the parameters of adherence to prescription. The aim of this prospective study was to evaluate adherence of oral antineoplastic agents and to investigate two calculation methods of adherence score. Patients and Methods: Twenty-nine cancer patients were enrolled in this study. Fourteen were treated by capecitabine and 15 patients by aromatase inhibitors. Adherence was measured using a medication event monitoring system and adherence score was calculated by a usual method and a composite adherence score that takes into account missed doses and also intake interval errors (between 2 doses and between meals). Results: Across the 6-month evaluation period, average adherence was 95% with the standard calculation (capecitabine group: 89%; aromatase inhibitor group: 99%) versus 83% with the composite index (capecitabine group: 62%; aromatase inhibitor group: 99%) (p = 0.030). The composite calculation permits to highlight more nonadherent patients (29.6 vs. 7.4%), particularly in the capecitabine group (73 vs. 18%, p = 0.001). We report 2 cases identified as nonadherent with composite adherence rate. Conclusion: The composite adherence score permits to better evaluate adherence to prescription and to identify barriers to adherence and persistence.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: April 12, 2012
Accepted: July 13, 2012
Published online: October 31, 2012
Issue release date: December 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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