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Vol. 34, No. 2, 2012
Issue release date: September 2012
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2012;34:96–111

Neuropsychiatric Symptoms and Global Functional Impairment along the Alzheimer’s Continuum

Wadsworth L.P.b · Lorius N.a,b · Donovan N.J.a,d · Locascio J.J.b · Rentz D.M.a,b · Johnson K.A.a,c · Sperling R.A.a,b · Marshall G.A.a,b
aCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Departments of bNeurology and cRadiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., and dDepartment of Psychiatry, Cambridge Health Alliance, Cambridge, Mass., USA

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Background/Aims: Neuropsychiatric symptoms in Alzheimer’s disease (AD) are highly prevalent. We sought to determine whether neuropsychiatric symptoms were related to global functional impairment at baseline and over a 3-year period in older normal control (NC), mild cognitive impairment (MCI) and mild AD dementia subjects. Methods: Eight hundred and twelve subjects (229 NC, 395 MCI, 188 AD) from the Alzheimer’s Disease Neuroimaging Initiative study underwent cognitive and behavioral assessments over 3 years. Results: Greater hallucinations, anxiety and apathy were associated with greater global functional impairment at baseline, while the presence of hallucinations and apathy at baseline was associated with greater global functional impairment over time across all subjects. The following neuropsychiatric symptoms were not significantly associated with global functioning: delusions, agitation, depression, euphoria, disinhibition, irritability, aberrant motor behaviors, sleep and appetite. Conclusions: These results suggest that increased baseline hallucinations, apathy and anxiety are associated with current and future disease progression in AD.

© 2012 S. Karger AG, Basel



  Article Information

Accepted: July 24, 2012
Published online: August 28, 2012
Number of Print Pages : 16


Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 34, No. 2, Year 2012 (Cover Date: September 2012)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 7/23/2012
Published online: 8/28/2012
Issue release date: September 2012

Number of Print Pages: 16
Number of Figures: 5
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

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Copyright / Drug Dosage

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