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7, No. 4, 2012
Issue release date: August 2012
Section title: Review Article · Übersichtsarbeit
Free Access
Breast Care 2012;7:267–272

Immunomodulation via Chemotherapy and Targeted Therapy: A New Paradigm in Breast Cancer Therapy?

Stagg J.a · Andre F.b · Loi S.c
aCentre de Recherche du Centre Hospitalier de l’Université de Montréal, Faculté de Pharmacie et Institut du Cancer de Montréal, Montréal, Québec, Canada bINSERM Unit 981, Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France cBreast Cancer Translational Research Laboratory (BCTL), Institut Jules Bordet, Brussels, Belgium

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Cytotoxic chemotherapy in the treatment of tumors has traditionally been thought to be immunosuppressive. Increasing evidence suggests the contrary and has introduced the concept of ‘immunogenic’ chemotherapy or, in other words, the concept that the innate and adaptive immune systems are critical in determining the longterm efficacy of some cytotoxic-based (and radiotherapy-based) regimens. The underlying mechanisms how these therapies can stimulate an antitumor immune response have been demonstrated recently. In this article, we review the background of this new paradigm and how combinations of traditional agents with the new immunotherapeutic therapies may significantly advance our treatment of breast cancer.

© 2012 S. Karger AG, Basel


Author Contacts

Dr. Sherene Loi, MD, PhD
Breast Cancer Translational Research Laboratory (BCTL)
Institut Jules Bordet
Boulevard de Waterloo 121, Brussels B1000, Belgium
Tel. +32 2 541-3457/3107, Fax -3199


Article Information

Published online: August 13, 2012
Number of Print Pages : 6


Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 7, No. 4, Year 2012 (Cover Date: August 2012)

Journal Editor: Harbeck N. (München), Thomssen C. (Halle/Saale), Gnant M. (Wien)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

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Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: 8/13/2012
Issue release date: August 2012

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information:

Copyright / Drug Dosage

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