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Vol. 229, No. 1, 2013
Issue release date: December 2012
Section title: EURETINA – Original Paper
Ophthalmologica 2013;229:26–31
(DOI:10.1159/000342196)

The Effects of Topical Coenzyme Q10 and Vitamin E d-α-Tocopheryl Polyethylene Glycol 1000 Succinate after Cataract Surgery: A Clinical and in vivo Confocal Study

Fogagnolo P. · Sacchi M. · Ceresara G. · Paderni R. · Lapadula P. · Orzalesi N. · Rossetti L.
aG.B. Bietti Foundation for the Study and Research in Ophthalmology, IRCCS, Rome, and bEye Clinic, San Paolo Hospital, University of Milan, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of EURETINA – Original Paper

Received: 5/29/2012 1:37:13 PM
Accepted: 7/26/2012
Published online: 9/20/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Purpose: To evaluate the postoperative effects of topical coenzyme Q10 + vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate (CoQ10) after cataract surgery. Methods: 40 consecutive patients were randomized to receive CoQ10 or saline solution (SS) twice daily for 9 months after uneventful cataract surgery with a temporal port. Before surgery, on day 14 and at months 3, 6 and 9, they underwent non-invasive break-up time (NIBUT) testing, Schirmer test, BUT, aesthesiometry as well as in vivo confocal microscopy of the subbasal nerve plexus of the cornea (SBP). The density of the subbasal nerves was calculated in the central (CFD) and temporal (TFD) cornea (number of fibres per field). Results: On day 14, surgery reduced CFD and TFD, respectively, by 25–35 and 50%; indices of ocular surface stability were all impaired. The treatment with CoQ10 was associated with faster nerve regeneration than SS (at month 3, CFD +1.5 ± 1.9 vs. +0.2 ± 1.8, p = 0.04, and TFD +2.5 ± 1.7 vs. +1.0 ± 1.6, p = 0.007; at month 6, TFD +2.7 ± 1.9 vs. +1.4 ± 1.5, p = 0.02) and better stability of ocular surface (NIBUT and BUT) throughout the study. No relevant side effects were found, apart from occasional burning in 10% of CoQ10 patients. Conclusions: Changes of the corneal nerves occurring after cataract surgery may influence the integrity of the ocular surface. Treatment with topical CoQ10 has a positive effect in restoring SBP anatomy and ocular surface stability.


  

Author Contacts

Paolo Fogagnolo, MD
Eye Clinic, San Paolo Hospital
Via di Rudiní 8
IT–20142 Milan (Italy)
Tel. +39 028 184 4301, E-Mail fogagnolopaolo@googlemail.com

  

Article Information

Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Fla., USA, May 2010.

Received: May 29, 2012
Accepted after revision: July 26, 2012
Published online: September 20, 2012
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 26

  

Publication Details

Ophthalmologica (The Journal of the European Society of Retina Specialists)

Vol. 229, No. 1, Year 2013 (Cover Date: December 2012)

Journal Editor: Cunha-Vaz J. (Coimbra)
ISSN: 0030-3755 (Print), eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


Article / Publication Details

First-Page Preview
Abstract of EURETINA – Original Paper

Received: 5/29/2012 1:37:13 PM
Accepted: 7/26/2012
Published online: 9/20/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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