Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative NeoplasmsHauck G. · Jonigk D. · Kreipe H. · Hussein K.
Institute of Pathology, Hannover Medical School, Hannover, Germany
Concurrent manifestation of two chronic-stage myeloid and lymphoid/plasmacytoid neoplasms in one patient is rare and occurs in ≤1% of patients. There has been no systematic analysis of which combinations are frequent/infrequent and whether two concurrent diseases in one patient are clonally related or represent independent diseases. We therefore characterised a series of cases from our own archive (n = 65) and collected a large number of previously reported cases of patients in whom myeloid and lymphoid/plasmacytoid neoplasms co-occurred (n = 185). The most frequent combination was Philadelphia chromosome-negative myeloproliferative neoplasm with concurrent B cell chronic lymphocytic leukaemia, accounting for approximately 50% of double-disease patients. We compared the quantity of unsorted bone marrow cell-derived JAK2V617F and KITD816V alleles with the quantity of the lymphoid/plasmacytoid compartment and analysed a subfraction of cases with fluorescence in situ hybridisation. Although a common aberrant progenitor has been reported in some cases in the literature, we found evidence of two independent chronic-stage myeloid and lymphoid/plasmacytoid neoplasms.
Dr. med. Kais Hussein
Institute of Pathology, Hannover Medical School
DE–30625 Hannover (Germany)
Received: June 21, 2012
Accepted after revision: August 8, 2012
Published online: December 21, 2012
Number of Print Pages : 10
Number of Figures : 3, Number of Tables : 1, Number of References : 103
Additional supplementary material is available online - Number of Parts : 1
Vol. 129, No. 3, Year 2013 (Cover Date: April 2013)
Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)
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