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Table of Contents
Vol. 129, No. 1, 2013
Issue release date: January 2013
Section title: Original Paper
Acta Haematol 2013;129:48–54
(DOI:10.1159/000342493)

Translocation t(11;17) in de novo Myelodysplastic Syndrome Not Associated with Acute Myeloid or Acute Promyelocytic Leukemia

Baljevic M.a · Abdel-Wahab O.b, c · Rampal R.b · Maslak P.G.b · Klimek V.M.b · Rosenblat T.L.b · Douer D.b · Levine R.L.b, c · Tallman M.S.b
aDepartment of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, bLeukemia Service, and cHuman Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 19, 2012
Accepted: August 09, 2012
Published online: November 07, 2012
Issue release date: January 2013

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Translocation t(11;17) is a well-recognized variant of acute promyelocytic leukemia (APL) and has also been identified in patients with mixed-lineage leukemia (MLL) non-APL acute myeloid leukemia. Here, we describe two patients bearing translocation t(11;17) presenting with a clinical diagnosis of de novo myelodysplastic syndrome (MDS): the first with sole karyotypic abnormality 46,XY,t(11;17)(p11.2; p13) and the second where it represented one of the two karyotypic abnormalities 46,XX,del(5)(q13q33)46,XX,del(5)(q13q33),t(11;17)(q24;q23). Molecular characterization of both cases failed to identify fusion transcripts involving MLL or PLZF-RARA and no collaborating somatic mutations commonly found among MDS patients were seen in either case, suggesting the presence of an as yet unidentified oncogenic fusion protein.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 19, 2012
Accepted: August 09, 2012
Published online: November 07, 2012
Issue release date: January 2013

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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