Gender Differences in the Livers of Patients with Hepatocellular Carcinoma and Chronic Hepatitis C InfectionNishida N. · Arizumi T. · Hayaishi S. · Takita M. · Kitai S. · Yada N. · Hagiwara S. · Inoue T. · Minami Y. · Ueshima K. · Sakurai T. · Ikai I. · Kudo M.
aDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Kinki University, Osaka, bDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, and c Department of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
Objectives: A unique causative aspect of hepatocellular carcinoma (HCC) is a gender difference in its incidence. To determine the specific factors that contribute to a male predominance, we analyzed the clinicopathological factors, and genetic and epigenetic alterations of HCCs in male and female patients. Methods: We retrospectively analyzed three cohorts of patients: the first cohort consisted of 547 patients identified with the first event of HCC, the second cohort included 176 HCC patients, and the third 127 patients with chronic hepatitis C (CHC). Results: Male patients were found to have HCC more frequently than female patients in cases of non-cirrhotic liver (p = 0.0030 by the χ2 test), especially in hepatitis C-positive cases. However, there were no gender-specific differences in the genetic and epigenetic alterations of cancer-related genes. Deposition of iron was more severe in male CHC patients than in female patients. Conclusions: Male patients with CHC develop HCC more frequently when they have a non-cirrhotic liver than do female patients. This gender difference could be, at least partially, attributed to a different degree of iron deposition, which contributes to the development of HCC in the absence of liver cirrhosis in men with CHC.
Naoshi Nishida, MD
Department of Gastroenterology and Hepatology
Kinki University School of Medicine, 377-2 Ohno-Higashi
Osaka-Sayama, Osaka 589-8511 (Japan)
Published online: December 13, 2012
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 1, Number of References : 20
Digestive Diseases (Clinical Reviews)
Vol. 30, No. 6, Year 2012 (Cover Date: December 2012)
Journal Editor: Malfertheiner P. (Magdeburg)
ISSN: 0257-2753 (Print), eISSN: 1421-9875 (Online)
For additional information: http://www.karger.com/DDI