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Vol. 35, No. 5-6, 2013
Issue release date: May 2013
Section title: Original Research Article
Dement Geriatr Cogn Disord 2013;35:340-350
(DOI:10.1159/000343074)

Aromatase Variants Modify Risk for Alzheimer's Disease in a Multiethnic Female Cohort

Janicki S.C. · Park N. · Cheng R. · Schupf N. · Clark L.N. · Lee J.H.
aTaub Institute for Research on Alzheimer's Disease and the Aging Brain, bGertrude H. Sergievsky Center, Departments of cNeurology, dPsychiatry and ePathology and Cell Biology and fCenter for Human Genetics, College of Physicians and Surgeons, Columbia University, and gDepartments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, N.Y., USA

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Article / Publication Details

Accepted: 8/27/2012
Published online: 4/18/2013

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: Few studies of gene variants that affect estrogen activity investigate their association with risk for Alzheimer's disease (AD) in women of different ethnicities. We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women, with individual ethnicity assessed by genetic population ancestry informative markers (AIMs) as well as by self-identified ethnicity. Methods: Among 1,686 women participating in the Washington Heights Inwood Columbia Aging Project, association with risk for AD was assessed for 41 single nucleotide polymorphisms (SNPs) on the CYP19 gene using multivariable logistic regression, adjusting for age, presence of an APOE ε4 allele, years of education, and body mass index. Results: Risk for AD was associated with 6 SNPs in women of predominantly Caucasian AIMs-defined ancestry. Of these, 2 were also associated with decreased risk of AD in women of admixed/Hispanic AIMs ancestry. Two separate SNPs were found to be protective in women of predominantly African AIMs-based ancestry. Conclusions:CYP19 polymorphisms affect risk for AD in women, and risk alleles vary by AIMs-defined ancestry. These effects are possibly due to linkage disequilibrium patterns or differences in the prevalence of comorbid risk factors mediating the SNP effect on risk for AD by group.


  

Author Contacts

Sarah C. Janicki, MD, MPH
Gertrude H. Sergievsky Center, Columbia University Medical Center
P&S Box 16, 622 West 168th Street
New York, NY 10032 (USA)
E-Mail scj2110@columbia.edu

  

Article Information

Accepted: August 27, 2012
Published online: April 18, 2013
Number of Print Pages : 11
Number of Figures : 1, Number of Tables : 3, Number of References : 31
Additional supplementary material is available online - Number of Parts : 3

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 35, No. 5-6, Year 2013 (Cover Date: May 2013)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

Accepted: 8/27/2012
Published online: 4/18/2013

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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