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Vol. 61, No. 3, 2012
Issue release date: November 2012
Section title: Paper
Ann Nutr Metab 2012;61:207–212
(DOI:10.1159/000343106)

A History of Vitamin E

Niki E. · Traber M.G.
aHealth Research Institute, AIST, Ikeda, Japan; bLinus Pauling Institute, Oregon State University, Corvallis, Oreg., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/26/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Vitamin E (α-tocopherol) was discovered nearly 100 years ago because it was required to prevent fetal resorption in pregnant, vitamin E-deficient rats fed lard-containing diets that were easily oxidizable. The human diet contains eight different vitamin E-related molecules synthesized by plants; despite the fact that all of these molecules are peroxyl radical scavengers, the human body prefers α-tocopherol. The biological activity of vitamin E is highly dependent upon regulatory mechanisms that serve to retain α-tocopherol and excrete the non-α-tocopherol forms. This preference is dependent upon the combination of the function of α-tocopherol transfer protein (α-TTP) to enrich the plasma with α-tocopherol and the metabolism of non-α-tocopherols. α-TTP is critical for human health because mutations in this protein lead to severe vitamin E deficiency characterized by neurologic abnormalities, especially ataxia and eventually death if vitamin E is not provided in large quantities to overcome the lack of α-TTP. α-Tocopherol serves as a peroxyl radical scavenger that protects polyunsaturated fatty acids in membranes and lipoproteins. Although specific pathways and specific molecular targets have been sought in a variety of studies, the most likely explanation as to why humans require vitamin E is that it is a fat-soluble antioxidant.


  

Author Contacts

Maret G. Traber, PhD
Linus Pauling Institute, Oregon State University
307 Linus Pauling Science Center
Corvallis, OR 97331 (USA)
E-Mail maret.traber@oregonstate.edu

  

Article Information

Published online: November 26, 2012
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 0, Number of References : 45

  

Publication Details

Annals of Nutrition and Metabolism

Vol. 61, No. 3, Year 2012 (Cover Date: November 2012)

Journal Editor: Koletzko B. (Munich)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/26/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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