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Table of Contents
Vol. 129, No. 2, 2013
Issue release date: February 2013
Section title: Original Paper
Acta Haematol 2013;129:65–71
(DOI:10.1159/000343616)

Refining the Diagnosis and Prognostic Categorization of Acute Myeloid Leukemia Patients with an Integrated Use of Cytogenetic and Molecular Studies

Costa D.a · Vidal A.a · Carrió A.a · Muñoz C.a · Arias A.a · Gómez C.a · Berneaga D.a · Colomer D.a · Rozman M.a · Pratcorona M.b · Torrebadell M.b · Díaz-Beyá M.b · Esteve J.b · Campo E.a
aHematopathology Section, Hospital Clínic, and bHematology Department, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Catalonia, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 04, 2012
Accepted: September 18, 2012
Published online: November 15, 2012
Issue release date: February 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Significant progress in the understanding of the genetic basis of acute myeloid leukemia (AML) has been made during the last 30 years. The aim of the present study was to assess whether the detection of recurrent gene rearrangements by fluorescent in situ hybridization (FISH) studies and NPM1 and FLT3 gene mutations by molecular studies added clinically relevant information to the karyotype in 113 AML patients. Thus, FISH and molecular studies were found to add new information in 22 and 55% of the patients, respectively, particularly in cases with normal karyotype (NK) or when a cytogenetic analysis failed. Patients with NK changed their genetic risk group to favorable in 27 and 29% of cases using FISH and molecular biology studies, respectively. Our results demonstrate that molecular biology and FISH studies provide relevant information in AML and should be routinely performed.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 04, 2012
Accepted: September 18, 2012
Published online: November 15, 2012
Issue release date: February 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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