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Cover

Cancer and Aging

From Bench to Clinics

Editor(s): Extermann M. (Tampa. Fla.) 
Table of Contents
Vol. 38, 2013
Section title: Paper
Extermann M (ed): Cancer and Aging. From Bench to Clinics. Interdiscipl Top Gerontol. Basel, Karger, 2013, vol 38, pp 1–16
(DOI:10.1159/000343625)

Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?

Sharp Z.D.a,c,d · Curiel T.J.b–d · Livi C.B.a,c,d
aDepartment of Molecular Medicine, Institute of Biotechnology, bDepartment of Medicine/Hematology and Medical Oncology, cBarshop Institute for Longevity and Aging Studies, and dCancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Tex., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 17, 2013
Cover Date: 2013

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-02306-0 (Print)
eISBN: 978-3-318-02307-7 (Online)

Abstract

Cancer and aging appear to be inexorably linked, yet approaches to ameliorate them in concert are lacking. Although not (easily) feasible in humans, years of preclinical research show that diet and growth factor restriction each successfully address cancer and aging together. Chronic treatment of genetically heterogeneous mice with an enteric formulation of rapamycin (eRapa) extended maximum lifespan of both genders when started in mid or late life. In part, cancer amelioration in treated mice suggested that long-term eRapa, like diet restriction, could be a pharmacological approach feasible for use in the clinic. We review the current understanding of the role of the mechanistic target of rapamycin (mTOR) in cancer and aging. We also discuss the tumor immune surveillance system, and the need for a better understanding of its responses to mTOR inhibitors. We also address the issue of the misperception that rapamycin is a potent immunosuppressant. Finally, we review the current state of mTOR inhibitors in the cancer clinic. Because of the burgeoning elderly population most at risk for cancer, there is a great need for our eRapa findings to be a proof of concept for the development of new and more comprehensive approaches to cancer prevention that are safe and also mitigate other deleterious effects of aging.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 17, 2013
Cover Date: 2013

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-02306-0 (Print)
eISBN: 978-3-318-02307-7 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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