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Table of Contents
7, No. 5, 2012
Issue release date: October 2012
Section title: Review Article · Übersichtsarbeit
Free Access
Breast Care 2012;7:378–382

Role of Breast Surgery in BRCA Mutation Carriers

Nestle-Krämling C.a · Kühn T.b
aDepartment of Senology, Sana Krankenhaus Düsseldorf-Gerresheim, bKlinik für Frauenheilkunde und Geburtshilfe, Klinikum Esslingen, Germany
email Corresponding Author

Dr. Carolin Nestle-Krämling

Department of Senology

Sana Krankenhaus Düsseldorf-Gerresheim

Graeulinger Straße 120, 40625 Düsseldorf, Germany


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BRCA mutation carriers have a life-long breast cancer risk between 55 and 85% and a high risk of developing breast cancer at a very young age, depending on the type of mutation. The risk of developing contralateral breast cancer after a first breast cancer is elevated up to 65%, especially in case of BRCA1 mutation and young age at the first breast cancer. Since bilateral prophylactic mastectomy is associated with a risk reduction of 90–95% of developing primary or contralateral breast cancer, this option is a key point within the counseling process for patient information and shared decision-making of mutation carriers. Although the local control after breast-conserving therapy in mutation carriers seems to be comparable to that of sporadic breast cancer patients, individual patient information and counseling should include all alternative procedures of oncologically adequate mastectomy techniques and immediate reconstruction. Excellent cosmetic results, high levels of life quality, and good patient acceptance can be achieved with the recent developments in reconstructive surgery of the breast.

Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: October 23, 2012
Issue release date: October 2012

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC

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