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Vol. 74, No. 5, 2012
Issue release date: January 2013
Section title: Original Paper
ORL 2012;74:264–270
(DOI:10.1159/000343796)

Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma

Tan W.J. · Chia C.S. · Tan H.K. · Soo K.-C. · Iyer N.G.
aDepartment of Surgical Oncology, National Cancer Centre Singapore, and bDepartment of General Surgery, Singapore General Hospital, Singapore

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/1/2012 1:17:39 PM
Accepted: 9/4/2012
Published online: 11/2/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 6

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Purpose: Staging for tongue carcinoma does not consider its depth of invasion. We aim to determine the prognostic significance of invasion depth in tongue cancer. Materials and Methods: Retrospective review of patients with tongue carcinoma who underwent curative surgery between 2002 and 2005; 67 patients were analyzed. Tumors were divided into 2 groups: group A = invasion depth <4 mm; group B = invasion depth ≥4 mm. Recurrence and survival rates were calculated for each group and compared. Results: The local recurrence rate in group B was significantly higher (10 vs. 29.7%, p = 0.048). Group A patients had a superior 5-year overall survival (68.8 vs. 41.6%, p = 0.012), disease-specific survival (67.1 vs. 41.1%, p = 0.026) and local recurrence-free survival (89.5 vs. 65.4%, p = 0.035). Five-year regional recurrence, locoregional recurrence and distant recurrence-free survival rates were not significantly different between the 2 groups (p = 0.390, p = 0.173 and p = 0.207). The impact of invasion depth on survival was maintained on multivariate analysis (p = 0.031). Conclusion: Invasion depth is an important prognostic indicator in tongue cancer.


  

Author Contacts

Dr. N. Gopalakrishna Iyer
National Cancer Centre Singapore
11 Hospital Drive
Singapore 169610 (Singapore)
E-Mail gopaliyer@yahoo.com

  

Article Information

Received: July 1, 2012
Accepted after revision: September 4, 2012
Published online: November 2, 2012
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 6, Number of References : 18

  

Publication Details

ORL (Journal for Oto-Rhino-Laryngology, Head and Neck Surgery)

Vol. 74, No. 5, Year 2012 (Cover Date: January 2013)

Journal Editor: O'Malley Jr. B.W. (Philadelphia, Pa.)
ISSN: 0301-1569 (Print), eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/1/2012 1:17:39 PM
Accepted: 9/4/2012
Published online: 11/2/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 6

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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