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Vol. 84, No. 2, 2013
Issue release date: December 2012
Section title: Clinical Translational Research
Oncology 2013;84:100–107
(DOI:10.1159/000343822)

Prognostic Significance of a Systemic Inflammatory Response in Patients Undergoing Multimodality Therapy for Advanced Colorectal Cancer

Inoue Y. · Iwata T. · Okugawa Y. · Kawamoto A. · Hiro J. · Toiyama Y. · Tanaka K. · Uchida K. · Mohri Y. · Miki C. · Kusunoki M.
aDivision of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, and bDepartment of Surgery, Ueno Municipal Hospital, Iga, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: 8/13/2012 4:36:40 PM
Accepted: 9/17/2012
Published online: 11/9/2012
Issue release date: December 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: The inflammation-based Glasgow Prognostic Score (GPS) is associated with outcome in a variety of cancers. This study investigated whether a modified GPS (mGPS) could predict survival in patients undergoing multimodality therapy for advanced colorectal cancer (CRC). Methods: We enrolled 245 patients with advanced CRC who received chemotherapy. The mGPS was recorded prior to first-line chemotherapy and to cytoreductive therapy including secondary surgery and/or radiofrequency ablation. The prognostic significance of the mGPS was analyzed using Kaplan-Meier, univariate, and multivariate analyses. Results: In patients who received chemotherapy alone (n = 163), the mGPS prior to chemotherapy was an independent prognostic indicator of survival [odds ratio (OR) 1.858; 95% confidence interval (CI) 1.213–2.846; p = 0.0044]. In patients who also underwent cytoreductive therapy (n = 82), the mGPS decreased after chemotherapy in 22 patients (27%) and increased in 5 (6%). In these patients, the mGPS prior to cytoreductive therapy was an independent prognostic indicator of survival (OR 3.412; 95% CI 1.198–9.720; p = 0.0216), but the mGPS prior to chemotherapy was not. Conclusions: The mGPS is an independent prognostic indicator of survival in patients undergoing multimodality therapy for advanced CRC, if recorded at a relevant time point.


  

Author Contacts

Yasuhiro Inoue, MD, Division of Reparative Medicine
Department of Gastrointestinal and Pediatric Surgery
Institute of Life Sciences, Mie University Graduate School of Medicine
2-174 Edobashi, Tsu, Mie 514-8507 (Japan)
E-Mail yasinoue@clin.medic.mie-u.ac.jp

  

Article Information

Received: August 13, 2012
Accepted after revision: September 17, 2012
Published online: November 9, 2012
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 5, Number of References : 28

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 84, No. 2, Year 2013 (Cover Date: December 2012)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: 8/13/2012 4:36:40 PM
Accepted: 9/17/2012
Published online: 11/9/2012
Issue release date: December 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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