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Vol. 62, No. 3, 2013
Issue release date: May 2013
Section title: Original Paper
Ann Nutr Metab 2013;62:223-230
(DOI:10.1159/000345026)

A Weight Loss Diet Intervention Has a Similar Beneficial Effect on Both Metabolically Abnormal Obese and Metabolically Healthy but Obese Premenopausal Women

Ruiz J.R. · Ortega F.B. · Labayen I.
aDepartment of Physical Education, School of Sport Sciences, University of Granada, Granada, and bDepartment of Nutrition and Food Science, University of the Basque Country, UPV/EHU, Vitoria, Spain; cDepartment of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden; dDepartment of Medical Physiology, School of Medicine, University of Granada, Granada, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/19/2012
Accepted: 10/10/2012
Published online: 4/5/2013

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: We studied the effect of a 12-week energy-restricted diet intervention on cardiometabolic risk in two groups of nonmorbid obese premenopausal Caucasian women, i.e. a metabolically abnormal obese (MAO) and a metabolically healthy but obese (MHO) group. Methods: The participants were 53 MAO and 25 MHO women (age range 19-49 years; body mass index inclusion criterion: 30-39.9). We assessed changes in body weight and composition, blood lipids, insulin resistance, hepatic enzymes, inflammatory markers and adipocytokines. Results: Overall, many of the study outcomes improved with the intervention in both MAO and MHO participants, but there was no difference in the magnitude of change between the groups. Body weight, waist circumference and total fat mass decreased significantly in response to the intervention in both MAO and MHO women (all p < 0.001). Fasting insulin, insulin resistance (homeostasis model assessment), hepatic enzymes (alanine aminotransferase and γ-glutamyltransferase), fatty liver index and leptin levels also decreased in both groups after the intervention (all p < 0.001), whereas total cholesterol, triglycerides and C-reactive protein decreased significantly only in MAO women (all p < 0.001). Conclusion: These findings reinforce the idea that MHO women would also benefit from a lifestyle weight reduction intervention.


  

Author Contacts

Idoia Labayen, PhD
Department of Nutrition and Food Science, University of the Basque Country
UPV/EHU, Paseo de la Universidad, 7
ES-01006 Vitoria (Spain)
E-Mail idoia.labayen@ehu.es

  

Article Information

Received: July 19, 2012
Accepted after revision: October 10, 2012
Published online: April 5, 2013
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 2, Number of References : 41

  

Publication Details

Annals of Nutrition and Metabolism

Vol. 62, No. 3, Year 2013 (Cover Date: May 2013)

Journal Editor: Koletzko B. (Munich)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/19/2012
Accepted: 10/10/2012
Published online: 4/5/2013

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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