A and B Blood Group Antigens in Human Pancreatic Ductal AdenocarcinomasHandra-Luca A.
Departments of Pathology, and Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Md., USA; Université Paris 13/Nord Sorbonne Cité APHP, Bobigny, France
Objectives: The aim of this study was to determine the clinicopathological significance of blood group expression patterns in patients with surgically resected pancreatic ductal adenocarcinomas. Methods: Pancreatic ductal adenocarcinomas from 459 patients were analyzed for immunohistochemical expression of A and B blood group antigens on tissue microarrays. Correlations were established by Fisher’s test, χ2 test, and logistic regression models, and relationships to postsurgical overall survival were analyzed by Kaplan-Meier method, log-rank test, and multivariate Cox models. Results: Tumors expressing blood group A antigen predicted fewer lymph node metastases (<3) and had longer postoperative survival by univariate and multivariate analysis. Loss of A antigen tumor expression in A blood group type patients correlated to vascular invasion. Conclusion: In patients with resectable pancreatic ductal adenocarcinomas, blood group A antigen expression predicted fewer lymph node metastases and was associated with improved outcome after pancreaticoduodenectomy.
© 2012 S. Karger AG, Basel
Received: September 6, 2012
Accepted after revision: September 28, 2012
Published online: December 14, 2012
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 6, Number of References : 37
Oncology (International Journal for Cancer Research and Treatment)
Vol. 84, No. 3, Year 2013 (Cover Date: January 2013)
Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)
For additional information: http://www.karger.com/OCL