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Vol. 84, No. 3, 2013
Issue release date: January 2013
Section title: Clinical Translational Research
Oncology 2013;84:141–149
(DOI:10.1159/000345028)

A and B Blood Group Antigens in Human Pancreatic Ductal Adenocarcinomas

Handra-Luca A.
Departments of Pathology, and Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Md., USA; Université Paris 13/Nord Sorbonne Cité APHP, Bobigny, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: 9/6/2012 10:45:26 AM
Accepted: 9/28/2012
Published online: 12/14/2012

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: The aim of this study was to determine the clinicopathological significance of blood group expression patterns in patients with surgically resected pancreatic ductal adenocarcinomas. Methods: Pancreatic ductal adenocarcinomas from 459 patients were analyzed for immunohistochemical expression of A and B blood group antigens on tissue microarrays. Correlations were established by Fisher’s test, χ2 test, and logistic regression models, and relationships to postsurgical overall survival were analyzed by Kaplan-Meier method, log-rank test, and multivariate Cox models. Results: Tumors expressing blood group A antigen predicted fewer lymph node metastases (<3) and had longer postoperative survival by univariate and multivariate analysis. Loss of A antigen tumor expression in A blood group type patients correlated to vascular invasion. Conclusion: In patients with resectable pancreatic ductal adenocarcinomas, blood group A antigen expression predicted fewer lymph node metastases and was associated with improved outcome after pancreaticoduodenectomy.


  

Author Contacts

Adriana Handra-Luca, MD, PhD
Sydney Kimmel Comprehensive Cancer Center
Johns Hopkins Medical Institutions
CRB2 342, 1550 Orleans St., Baltimore, MD 21231 (USA)
or
APHP Avicenne Université Paris 13/Nord Sorbonne Cité
Batiment Lavoisier, 125 rue de Stalingrad
FR–93000 Bobigny (France)
E-Mail adriana.handra-luca@avc.aphp.fr

  

Article Information

Received: September 6, 2012
Accepted after revision: September 28, 2012
Published online: December 14, 2012
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 6, Number of References : 37

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 84, No. 3, Year 2013 (Cover Date: January 2013)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: 9/6/2012 10:45:26 AM
Accepted: 9/28/2012
Published online: 12/14/2012

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 6

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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