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Table of Contents
Vol. 161, No. 2, 2013
Issue release date: May 2013
Section title: Short Communication
Int Arch Allergy Immunol 2013;161:127–130
(DOI:10.1159/000345134)

Bed Bug Saliva Causes Release of Monocytic Inflammatory Mediators: Plausible Cause of Cutaneous Bite Reactions

Goddard J.a · Hasenkampf N.b · Edwards K.T.a · de Shazo R.c · Embers M.E.b
aDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, Miss., bDivision of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, La., and cDivision of Clinical Immunology and Allergy, Departments of Medicine and Pediatrics, University of Mississippi Medical Center, Jackson, Miss., USA

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: October 01, 2012
Accepted: October 10, 2012
Published online: January 23, 2013
Issue release date: May 2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE included those known to recruit eosinophils (eotaxin), attract neutrophils [interleukin (IL)-8] or induce their survival and proliferation (granulocyte colony-stimulating factor). Cytokines involved in cell-mediated immunity, including IL-7, IL-10 and IL-12, were also induced. Saliva of bed bugs contains protein and non-protein molecules that have pleotropic effects on macrophages, orchestrating the immune response in the skin after bed bug bites.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: October 01, 2012
Accepted: October 10, 2012
Published online: January 23, 2013
Issue release date: May 2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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