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Vol. 91, No. 3, 2013
Issue release date: May 2013
Section title: Laboratory Investigation
Stereotact Funct Neurosurg 2013;91:153-161
(DOI:10.1159/000345270)

Strategies for the Delivery of Multiple Collinear Infusion Clouds in Convection-Enhanced Delivery in the Treatment of Parkinson's Disease

Sillay K. · Hinchman A. · Kumbier L. · Schomberg D. · Ross C. · Kubota K. · Brady M. · Brodsky E. · Miranpuri G. · Raghavan R.
Departments of aNeurological Surgery and bBiomedical Engineering, University of Wisconsin, Madison, Wisc., cEngineering Resources Group, Pembroke Pines, Fla., dKinetics Foundation, Los Altos, Calif., and eTherataxis, Baltimore, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Laboratory Investigation

Received: 12/21/2011
Accepted: 10/15/2012
Published online: 2/27/2013

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Background: Delivery of multiple collinear payloads utilizing convection-enhanced delivery (CED) has historically been performed by retraction of a needle or catheter from the most distal delivery site. Few studies have addressed end-infusion morphology and associated payload reflux in stacked and collinear infusions, and studies comparing the advancement with the retraction mode are lacking. Objective: To compare advancement versus retraction mode infusion results. Methods: Infusion cloud pairs were created with the advancement and retraction technique in agarose gel using both open end-port SmartFlow™ (SF) and valve tip (VT) catheter infusion systems. Backflow, radius of infusion, and morphology were assessed. Results: Infusions with the SF catheter, in contrast to the VT catheter, exhibited significantly more backflow in retraction mode at the shallow infusion site. Infusion morphology differed with the second infusion after retraction: the infusate at the proximal site first filling the channel left by the retraction and then being convected into gel in a pronouncedly non-spherical shape during the second infusion. Conclusions: Significant differences in cloud morphology were noted with respect to external catheter geometry with retraction versus penetration between infusions in an agarose gel model of the brain. Further study is warranted to determine optimal protocols for human clinical trials employing CED with multiple collinear payloads.


  

Author Contacts

Dr. Karl Sillay
K4/842 Clinical Sciences Center
600 Highland Avenue
Madison, WI 53792 (USA)
E-Mail sillay@neurosurgery.wisc.edu

  

Article Information

Received: December 21, 2011
Accepted after revision: October 15, 2012
Published online: February 27, 2013
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 3, Number of References : 14
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Stereotactic and Functional Neurosurgery

Vol. 91, No. 3, Year 2013 (Cover Date: May 2013)

Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


Article / Publication Details

First-Page Preview
Abstract of Laboratory Investigation

Received: 12/21/2011
Accepted: 10/15/2012
Published online: 2/27/2013

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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