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Vol. 5, No. 3, 2012
Issue release date: September – December
Section title: Published: November 2012

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Case Rep Oncol 2012;5:608–615

Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report

Mukai S. · Takakura Y. · Egi H. · Hinoi T. · Saito Y. · Tanimine N. · Miguchi M. · Adachi T. · Shimomura M. · Ohdan H.
Department of Gastroenterological Surgery, Hiroshima University Hospital, Hiroshima, Japan

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Micropapillary carcinoma was originally reported to be an aggressive variant of breast carcinoma, and it is associated with frequent lymphovascular invasion and a dismal clinical outcome. It has subsequently been found in other organs; however, at present, only a limited number of cases of colorectal micropapillary carcinoma have been reported. We present a case of early colon cancer with extensive nodal metastases in a Japanese patient. An 82-year-old man was found by colonoscopy to have a 20-mm pedunculated polyp in his sigmoid colon. Endoscopic resection of the sigmoid colon tumor was performed, and pathological examination of the resected specimen revealed a poorly differentiated adenocarcinoma component and a micropapillary component. Despite the tumor being confined within the submucosa, massive lymphatic invasion was noted. Thereafter, the patient underwent laparoscopic sigmoidectomy with lymph node dissection, and multiple lymph node metastases were observed. Our case suggests that when a micropapillary component is identified in a pre-operative biopsy specimen, even for early colorectal cancer, surgical resection with adequate lymph node dissection would be required because of the high potential for nodal metastases.

© 2012 S. Karger AG, Basel


Author Contacts

Yuji Takakura, MD
Department of Gastroenterological Surgery
Hiroshima University Hospital
1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551 (Japan)


Article Information

Published online: November 20, 2012
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 1,


Publication Details

Case Reports in Oncology

Vol. 5, No. 3, Year 2012 (Cover Date: September - December)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 1662-6575 (Print), eISSN: 1662-6575 (Online)

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Article / Publication Details

First-Page Preview
Abstract of Published: November 2012

Published online: 11/20/2012
Issue release date: September – December

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: (Print)
eISSN: 1662-6575 (Online)

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Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (, applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
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