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Vol. 75, No. 2, 2013
Issue release date: February 2013
Section title: Novel Insights from Clinical Practice
Gynecol Obstet Invest 2013;75:139-144
(DOI:10.1159/000345863)

Two Cases of Malignant Struma Ovarii with Metastasis to Pelvic Bone

Steinman R.A. · De Castro I.O. · Shrayyef M. · Chengazi V. · Giampoli E. · Van Der Sloot P. · Calvi L.M. · Wittlin S.D. · Hammes S.R. · Hou R.
aDivision of Endocrinology and Metabolism, Departments of bRadiology, and cPathology, dDivision of Otolaryngology, University of Rochester School of Medicine, Rochester, N.Y., USA; eDepartment of Medicine, Moncton Hospital, Moncton, N.B., fDepartment of Medicine, Dalhousie University, Halifax, N.S., and gDepartment of Medicine, Memorial University, St. John, Nfld., Canada

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 1/9/2012 2:19:09 PM
Accepted: 11/14/2012
Published online: 2/5/2013

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Histologically, malignant struma ovarii metastasizes rarely, and only a few cases reported bone metastasis. Here, we describe 2 cases of biologically malignant struma ovarii with pelvic bone metastasis. Case 1 is a 22-year-old female who was found to have a large left ovarian mass during routine prenatal ultrasound. Papillary thyroid cancer arising in struma ovarii was identified after laparoscopic salpingo-oophorectomy. After total thyroidectomy, radioactive iodine whole-body scan revealed extrathyroidal iodine uptake in left anterior pelvis. Subsequent I-131 treatment resolved the pelvic metastasis. Case 2 is a 49-year-old female who was diagnosed with malignant struma ovarii in 1996 and presented in 2007 with pelvic recurrence and extensive left hip metastasis. Treatment with resection of the pelvic tumor, total thyroidectomy, and multiple I-131 ablation led to eventual resolution of the abdominal and left hip foci. In conclusion, we present 2 rare cases of malignant struma ovarii, both with metastasis to the pelvic bone. This report makes pelvic bone the most frequent site for bone metastasis in malignant struma ovarii. It also emphasizes the importance of total thyroidectomy in allowing identification and treatment of bony metastasis with radioactive iodine.


  

Author Contacts

Runhua Hou
Division of Endocrinology and Metabolism
University of Rochester School of Medicine
601 Elmwood Ave, Box 693, Rochester, NY 14642 (USA)
E-Mail runhua_hou@urmc.rochester.edu

  

Article Information

Received: January 9, 2012
Accepted after revision: November 14, 2012
Published online: February 6, 2013
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 0, Number of References : 25
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 75, No. 2, Year 2013 (Cover Date: February 2013)

Journal Editor: D'Hooghe T.M. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 1/9/2012 2:19:09 PM
Accepted: 11/14/2012
Published online: 2/5/2013

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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