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Vol. 84, Suppl. 1, 2013
Issue release date: February 2013
Section title: Paper
Oncology 2013;84(suppl 1):13-20
(DOI:10.1159/000345884)

Assessment of Liver Fibrosis with Real-Time Tissue Elastography in Chronic Viral Hepatitis

Yada N. · Kudo M. · Morikawa H. · Fujimoto K. · Kato M. · Kawada N.
aDepartment of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osakasayama, bDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, and cDivision of Clinical Research and dDepartment of Internal Medicine, National Hospital Organization, Minamiwakayama Medical Center, Tanabe, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/20/2013

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: The aim of this study was to assess prospectively the accuracy of measurement of liver fibrosis with real-time tissue elastography (RTE) in patients with chronic viral hepatitis. Methods: Two hundred and forty-five patients were prospectively enrolled. Nine image features were measured from strain images, and Liver Fibrosis Index (LFI) was calculated from these features. Fibrosis stage was diagnosed from pathological specimens obtained by ultrasound-guided biopsy. LFI and serological markers were compared with pathological diagnosis, and the diagnostic performance of RTE was compared. Results: LFI in stages F0-F1, F2, F3 and F4 was 1.58, 2.03, 2.40 and 2.86, respectively, demonstrating a stepwise increase with increasing severity of liver fibrosis (p < 0.001). LFI in F2 did not significantly differ from that in F3, whereas for all other combinations of stages, there were significant differences. The area under the receiver operating characteristic curve of the LFI, platelet count, aspartate/alanine aminotransferase ratio, aspartate aminotransferase-to-platelet ratio, and FibroIndex for predicting F3 stage or higher (F0-F2 vs. F3-F4) was 0.865, 0.824, 0.708, 0.789 and 0.828, respectively. Conclusions: RTE is useful for diagnosis of liver fibrosis, regardless of stage, in patients with chronic viral hepatitis.


  

Author Contacts

Masatoshi Kudo, MD, PhD
Division of Gastroenterology and Hepatology, Department of Internal Medicine
Kinki University Faculty of Medicine
377-2 Ohno-Higashi, Osakasayama, Osaka 589-8511 (Japan)
E-Mail m-kudo@med.kindai.ac.jp

  

Article Information

Published online: February 20, 2013
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 3, Number of References : 24

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 84, No. Suppl. 1, Year 2013 (Cover Date: February 2013)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/20/2013

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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