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Table of Contents
Vol. 103, No. 3, 2013
Issue release date: March 2013
Section title: Original Paper
Neonatology 2013;103:235–240
(DOI:10.1159/000346057)

Antibiotic Use in Newborns with Transient Tachypnea of the Newborn

Weintraub A.S.a, b · Cadet C.T.a, b · Perez R.a · DeLorenzo E.a · Holzman I.R.a, b · Stroustrup A.a–c
aDivision of Newborn Medicine, Kravis Children’s Hospital, Mount Sinai Medical Center, and Departments of bPediatrics and cPreventive Medicine, Mount Sinai School of Medicine, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 15, 2012
Accepted: November 20, 2012
Published online: February 14, 2013
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Initiation of empiric antibiotic treatment for possible early-onset sepsis is recommended for late preterm and term neonates with respiratory distress. There is no evidence base to this approach. Objectives: To determine the incidence of adverse infectious events in neonates with transient tachypnea of the newborn (TTN) managed with a risk-factor-based restrictive antibiotic use policy. Methods: This is a single institution retrospective cohort study of neonates with primary diagnosis of TTN between 2004 and 2010. The relationship between antibiotic exposure and infectious outcomes during the neonatal hospitalization was evaluated. An infectious outcome was defined as pneumonia, bacteremia, clinical sepsis, or death. Analysis included t test, χ2 test, and analysis of variance as appropriate. Results: 745 neonates with TTN met inclusion criteria. None of the 494 antibiotic-naive infants, and 212 of the 251 antibiotic-exposed infants had identifiable risk factors for sepsis. No infectious outcomes occurred in infants who did not receive antibiotics. Eight neonates with TTN received full antibiotic treatment for early-onset sepsis. Each was appropriately identified for early receipt of antibiotics based on historical or clinical risk factors for early-onset sepsis. Conclusions: This study suggests that empiric postnatal antibiotic treatment may not be warranted for late preterm and term infants with TTN in the absence of specific infectious risk factors.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 15, 2012
Accepted: November 20, 2012
Published online: February 14, 2013
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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