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Vol. 35, No. 1-3, 2013
Issue release date: June 2013
Section title: Original Paper
Blood Purif 2013;35:209-215
(DOI:10.1159/000346631)

Effects of Increasing Diffusive Sodium Removal on Blood Pressure Control in Hemodialysis Patients with Optimal Dry Weight

Zhou Y.-L. · Liu J. · Ma L.-J. · Sun F. · Shen Y. · Huang J. · Cui T.-G.
Department of Nephrology, Chao-Yang Hospital, Capital Medical University, Beijing, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2012 4:34:48 PM
Accepted: 12/11/2012
Published online: 3/19/2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Background: Sodium, apart from volume, may have an independent effect on blood pressure (BP) regulation. Methods: Sixteen hypertensive hemodialysis patients were enrolled, who have achieved their dry weight assessed by bioimpedance methods, with pre-dialysis plasma sodium levels slightly higher than the facility dialysate sodium concentration 138 mmol/l. After a 1-month period of dialysis with standard dialysate sodium concentration of 138 mmol/l, the patients were followed up for a 4-month period with dialysate sodium set at 136 mmol/l. Results: Along with lowering dialysate sodium, there were significant decreases (-10 mm Hg and -6 mm Hg) in 44-hour ambulatory systolic and diastolic BP at 4 months. Interdialytic weight gain adjusted to the estimated dry weight mildly but significantly decreased (4.81 ± 1.51 vs. 4.36 ± 1.37%, p = 0.047). The post-dialysis volume parameters remained constant throughout the study period. Conclusion: In selected hypertensive hemodialysis patients with optimal dry weight, increasing diffusive sodium removal resulted in significant BP decrease. It was probably due to a volume-independent effect.


  

Author Contacts

Tai-Gen Cui
Department of Nephrology, Chao-Yang Hospital
Capital Medical University, #8 South Gongti Road
Beijing 100020 (China)
E-Mail cuitaigen@yahoo.com

  

Article Information

Received: July 10, 2012
Accepted: December 11, 2012
Published online: March 19, 2013
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 31

  

Publication Details

Blood Purification

Vol. 35, No. 1-3, Year 2013 (Cover Date: June 2013)

Journal Editor: Ronco C. (Vicenza)
ISSN: 0253-5068 (Print), eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2012 4:34:48 PM
Accepted: 12/11/2012
Published online: 3/19/2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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