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Vol. 67, No. 3, 2013
Issue release date: April 2013
Section title: Case Report
Neuropsychobiology 2013;67:181-184
(DOI:10.1159/000346654)

EMDR Therapy Modulates the Default Mode Network in a Subsyndromal, Traumatized Bipolar Patient

Landin-Romero R. · Novo P. · Vicens V. · McKenna P.J. · Santed A. · Pomarol-Clotet E. · Salgado-Pineda P. · Shapiro F. · Amann B.L.
aFIDMAG Research Foundation Germanes Hospitalàries, bCIBERSAM, cDepartament de Psiquiatria i Medicina Legal, Doctorat de Psiquiatria i Psicología Clínica, Universitat Autònoma de Barcelona, dCentro Adala de Atencion Psicologica, Barcelona, Spain; eMental Research Institute, Palo Alto, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 8/7/2012 5:08:16 PM
Accepted: 12/14/2012
Published online: 3/16/2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.


  

Author Contacts

Dr. Benedikt L. Amann
FIDMAG Research Foundation
Dr. Antoni Pujadas 38
ES-08830 Sant Boi de Llobregat, Barcelona (Spain)
E-Mail benedikt.amann@gmail.com

  

Article Information

Received: August 7, 2012
Accepted after revision: December 14, 2012
Published online: March 16, 2013
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 18

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 67, No. 3, Year 2013 (Cover Date: April 2013)

Journal Editor: Strik W. (Bern)
ISSN: 0302-282X (Print), eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 8/7/2012 5:08:16 PM
Accepted: 12/14/2012
Published online: 3/16/2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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