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Table of Contents
Vol. 37, No. 2, 2013
Issue release date: March 2013
Section title: Original Report: Transplantation
Am J Nephrol 2013;37:126–134
(DOI:10.1159/000346711)

Longitudinal Analysis of Vascular Function and Biomarkers of Metabolic Bone Disorders before and after Renal Transplantation

Yilmaz M.I.a · Sonmez A.b · Saglam M.c · Yaman H.d · Kilic S.e · Turker T.e · Unal H.U.a · Gok M.a · Cetinkaya H.a · Eyileten T.a · Oguz Y.a · Caglar K.a · Vural A.a · Mallamaci F.f · Zoccali C.f
Departments of aNephrology, bEndocrinology, cRadiology, dBiochemistry and eEpidemiology, Gulhane School of Medicine, Ankara, Turkey; fNephrology, Hypertension and Renal Transplantation, CNR-IBIM Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Transplantation

Received: November 01, 2012
Accepted: December 31, 2012
Published online: January 31, 2013
Issue release date: March 2013

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aims: The role of chronic kidney disease-mineral bone disorder (CKD-MBD) reversibility in the amelioration of vascular function and in the reduction of the risk for cardiovascular events after renal transplantation is still unknown. Methods: We investigated the longitudinal relationship between the main biomarkers of CKD-MBD and the evolution of vascular function [flow-mediated dilatation (FMD)] after transplantation in a series of 161 patients with kidney failure maintained on chronic dialysis (5D-CKD). Results: Before transplantation, FMD in patients was markedly lower (–40%, p < 0.001) than in well-matched healthy subjects and increased by 27% after transplantation (p = 0.001). Fibroblast growth factor 23 (FGF23), 25-hydroxy-vitamin D (25OHVD) and serum phosphate (p < 0.01) were independently associated with simultaneous changes in FMD. Changes in classical risk factors and in risk factors related to CKD like the glomerular filtration rate, serum albumin, C-reactive protein and insulin resistance failed to independently explain the variability in FMD changes after transplantation. Conclusion: Endothelium-dependent vasodilatation improves after kidney transplantation, which is parallel to the dramatic fall in FGF23, the reduction in serum phosphorus and the increase in 25OHVD levels. If these associations are causal, a part of decline in cardiovascular risk after transplantation is related to partial resolution of CKD-MBD.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Transplantation

Received: November 01, 2012
Accepted: December 31, 2012
Published online: January 31, 2013
Issue release date: March 2013

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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