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Table of Contents
Vol. 124, No. 4, 2013
Issue release date: April 2013
Section title: Original Research
Cardiology 2013;124:233-240
(DOI:10.1159/000347126)

Increased Expression of Connective Tissue Growth Factor and Transforming Growth Factor-Beta-1 in Atrial Myocardium of Patients with Chronic Atrial Fibrillation

Li Y. · Jian Z. · Yang Z.Y. · Chen L. · Wang X.F. · Ma R.Y. · Xiao Y.B.
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, PR China

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Article / Publication Details

Received: December 06, 2012
Accepted: January 11, 2013
Published online: April 06, 2013
Issue release date: April 2013

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: This study aimed to investigate the roles of connective tissue growth factor (CTGF) and transforming growth factor-β1 (TGF-β1) in atrial fibrosis in patients with chronic atrial fibrillation. Methods: Up to 40 cases involving simple mitral valve replacement surgery were divided into 2 groups: the chronic atrial fibrillation (cAF) group (n = 28) and the sinus rhythm group (n = 12). Echocardiography was used to measure the cardiac cavity size and analyze the cardiac function. Right atrial specimens were obtained during the operation. The collagen volume fraction in the atrial specimens was examined. The mRNA and protein levels of TGF-β1, Smad3 and CTGF were also investigated. Results: Compared with the sinus rhythm group, the cAF group had higher collagen content in the right atrial tissues. The mRNA and protein levels of TGF-β1, Smad3 and CTGF were also significantly elevated in the cAF group (p < 0.05). The mRNA and protein levels of TGF-β1 and CTGF in the cAF group correlated positively with the collagen volume fraction. The positive correlation between the expression of TGF-β1 and CTGF was also demonstrated. Conclusions: CTGF is upregulated via the TGF-β1/Smad pathway in the atrial myocardium of cAF patients. Furthermore, the TGF-β1/Smad pathway may play an important role in the structural remodeling during atrial fibrosis.

© 2013 S. Karger AG, Basel


Article / Publication Details

Received: December 06, 2012
Accepted: January 11, 2013
Published online: April 06, 2013
Issue release date: April 2013

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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