Precursor B-Cell Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression in 2 Chinese PatientsLiu Y. · Zhai Y. · Zhang Y. · Cheng W. · Li Y.
Hematology Department, Henan Provincial People's Hospital, The People's Hospital of Zhengzhou University, Zhengzhou, China
Background: Precursor B-cell acute lymphocytic leukemia (ALL) with surface immunoglobulin light chain expression is a rare disease entity. The differential diagnosis is difficult but critical for disease management. Aims: We report 2 cases (1 adult and 1 infant) of precursor B-cell ALL who presented at diagnosis with surface immunoglobulin light chain expression revealed by flow cytometric immunophenotyping and discuss its clinical significance. Case Report: The 2 patients presented with nonspecific symptoms such as fever, pallor, fatigue or lymphadenopathy. Flow cytometric immunophenotyping showed that both patients expressed CD34/CD19/CD10/CD22/CD9/HLA-DR/CD38/CD123/CD13 (partial) and had unexpected single λ light chain expression. Cytogenetic analysis revealed t(9;22)(q34;q11) in the adult patient and normal karyotype in the infant. Both cases were diagnosed and managed as precursor B-ALL, and the patients showed good response to treatment regimens. Conclusion: We describe 2 cases of precursor B-ALL with unexpected surface light chain expression. The exceedingly rare immunophenotypes have diagnostic implication for immunophenotyping of this malignancy. Treatment regimens for precursor B-cell ALL are suitable for such cases.
© 2013 S. Karger AG, Basel
Received: June 18, 2012
Accepted after revision: January 4, 2013
Published online: June 11, 2013
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 13
Vol. 130, No. 3, Year 2013 (Cover Date: September 2013)
Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)
For additional information: http://www.karger.com/AHA