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Vol. 130, No. 3, 2013
Issue release date: September 2013
Section title: Case Report
Acta Haematol 2013;130:188-191
(DOI:10.1159/000347165)

Precursor B-Cell Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression in 2 Chinese Patients

Liu Y. · Zhai Y. · Zhang Y. · Cheng W. · Li Y.
Hematology Department, Henan Provincial People's Hospital, The People's Hospital of Zhengzhou University, Zhengzhou, China

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 6/18/2012 9:56:14 AM
Accepted: 1/4/2013
Published online: 6/11/2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Background: Precursor B-cell acute lymphocytic leukemia (ALL) with surface immunoglobulin light chain expression is a rare disease entity. The differential diagnosis is difficult but critical for disease management. Aims: We report 2 cases (1 adult and 1 infant) of precursor B-cell ALL who presented at diagnosis with surface immunoglobulin light chain expression revealed by flow cytometric immunophenotyping and discuss its clinical significance. Case Report: The 2 patients presented with nonspecific symptoms such as fever, pallor, fatigue or lymphadenopathy. Flow cytometric immunophenotyping showed that both patients expressed CD34/CD19/CD10/CD22/CD9/HLA-DR/CD38/CD123/CD13 (partial) and had unexpected single λ light chain expression. Cytogenetic analysis revealed t(9;22)(q34;q11) in the adult patient and normal karyotype in the infant. Both cases were diagnosed and managed as precursor B-ALL, and the patients showed good response to treatment regimens. Conclusion: We describe 2 cases of precursor B-ALL with unexpected surface light chain expression. The exceedingly rare immunophenotypes have diagnostic implication for immunophenotyping of this malignancy. Treatment regimens for precursor B-cell ALL are suitable for such cases.


  

Author Contacts

Prof. Yaping Zhai
Hematology Department
Henan Provincial People's Hospital,The People's Hospital of Zhengzhou University
7 Weiwu Street, Zhengzhou, Henan Province 450003 (China)
E-Mail platelet228@163.com

  

Article Information

Received: June 18, 2012
Accepted after revision: January 4, 2013
Published online: June 11, 2013
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 13

  

Publication Details

Acta Haematologica

Vol. 130, No. 3, Year 2013 (Cover Date: September 2013)

Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 6/18/2012 9:56:14 AM
Accepted: 1/4/2013
Published online: 6/11/2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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