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Vol. 92, No. 1, 2014
Issue release date: January 2014
Section title: Original Paper
Urol Int 2014;92:7-14
(DOI:10.1159/000351325)

Obesity and Prostate Cancer Incidence and Mortality: A Systematic Review of Prospective Cohort Studies

Golabek T. · Bukowczan J. · Chłosta P. · Powroźnik J. · Dobruch J. · Borówka A.
a1st Department of Urology, Postgraduate Medical Education Centre, European Health Centre, Otwock, and bDepartment of Urology, Collegium Medicum, Jagiellonian University, Cracow, Poland; cDepartment of Diabetes and Endocrinology, James Cook University Hospital, Middlesbrough, and dInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2012 11:22:47 AM
Accepted: 4/13/2013
Published online: 8/8/2013

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Background: There has been a large body of research on obesity and the risk of prostate cancer (PCa) that has been published recently. However, the epidemiological evidence for such an association has not been consistent. This may be attributed to the nature of case-control and retrospective studies, which generally are more prone to biases. Therefore, we conducted a systematic review of prospective cohort studies to assess the association between obesity and the risk of PCa incidence and death. Methods: A search of the PubMed database and references of published studies (from inception until March 2013) was conducted. Twenty-three eligible studies were identified and included in the systematic review. Results: The evidence from the prospective cohort studies linking obesity with PCa incidence has not been consistent. However, cumulative data is compelling for a strong positive association between obesity and fatal PCa. Conclusions: Obesity is a significant diet-related risk factor for fatal PCa. Further well-constructed, large cohort studies on the potential association between obesity and PCa, as well as on underlying mechanisms, are needed.


  

Author Contacts

Tomasz Golabek
1st Department of Urology, Postgraduate Medical Education Centre
European Health Centre in Otwock
Borowa 14/18, PL-05-400 Otwock (Poland)
E-Mail elementare@op.pl

  

Article Information

Received: December 28, 2012
Accepted after revision: April 13, 2013
Published online: August 8, 2013
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 2, Number of References : 61

  

Publication Details

Urologia Internationalis

Vol. 92, No. 1, Year 2014 (Cover Date: January 2014)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife), Wullich B. (Erlangen)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2012 11:22:47 AM
Accepted: 4/13/2013
Published online: 8/8/2013

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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