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Vol. 63, No. 3, 2013
Issue release date: December 2013
Section title: Original Paper
Ann Nutr Metab 2013;63:216-222
(DOI:10.1159/000351597)

Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment

Valle Jiménez M. · Martos R. · Morales R.M. · Valle R. · Cañete M.D. · Urbano M.M. · Bermudo F. · Cañete R.
aClinical Laboratory Department, Valle de los Pedroches Hospital, and bHealth Center of Pozoblanco, Pozoblanco, cSchool of Medicine and dGrupo PAIDI CTS-329 (IMIBIC), Universidad de Córdoba, and ePediatric Department, Reina Sofía Hospital, Córdoba, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/19/2012
Accepted: 4/18/2013
Published online: 10/15/2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity.


  

Author Contacts

Dr. Miguel Valle Jiménez
Clinical Laboratory Department, Valle de los Pedroches Hospital
C/Juan del Rey Calero s/n
ES-14400 Pozoblanco, Córdoba (Spain)
E-Mail vallej90@yahoo.es

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Article Information

Received: March 19, 2012
Accepted after revision: April 18, 2013
Published online: October 15, 2013
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 4, Number of References : 35

  

Publication Details

Annals of Nutrition and Metabolism

Vol. 63, No. 3, Year 2013 (Cover Date: December 2013)

Journal Editor: Koletzko B. (Munich)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/19/2012
Accepted: 4/18/2013
Published online: 10/15/2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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