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Vol. 76, No. 4, 2013
Issue release date: November 2013
Section title: Original Article
Gynecol Obstet Invest 2013;76:221-227
(DOI:10.1159/000355521)

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

Li C. · Qiao B. · Zhan Y. · Peng W. · Chen Z.-J. · Sun L. · Zhang J. · Zhao L. · Gao Q.
Departments of aObstetrics, bPediatrics and cGynecology, The Affiliated Hospital of Medical College, Qingdao University, dDepartment of Radiology, Qingdao Municipal Hospital, Qingdao, and eShandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 5/27/2013 10:27:57 AM
Accepted: 9/7/2013
Published online: 10/18/2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Background/Aims: The purpose of this study was to investigate the association between MTNR1A and MTNR1B gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women. Methods: Study participants included 350 patients with GDM and 480 control subjects. Three single-nucleotide polymorphisms (SNPs; rs2119882 in MTNR1A and rs10830963 and rs10830962 in MTNR1B) were genotyped using direct sequencing. Genotype and allele distributions of SNPs in cases of GDM and controls were analyzed. Association of the MTNR1A and MTNR1B gene variants with plasma glucose and insulin levels as well as blood lipid levels was further investigated. Results: The frequencies of genotypes and allele types of rs2119882 in MTNR1A and rs10830963 in MTNR1B were significantly different between women with GDM and controls (p < 0.05). Moreover, in the GDM group, these SNPs were associated with increased fasting plasma glucose concentrations (p < 0.001) and increased homeostasis model assessment of insulin resistance (p < 0.001). The rs10830962 polymorphism in MTNR1B was not associated with an increased risk of developing GDM or any of the clinical or metabolic characteristics in patients with GDM (p > 0.05). Conclusion: The genetic polymorphisms rs2119882 in MTNR1A and rs10830963 in MTNR1B are associated with an increased risk of developing GDM and insulin resistance in Han Chinese women.


  

Author Contacts

Chao Li
Department of Obstetrics
The Affiliated Hospital of Medical College
Qingdao University, Qingdao (China)
E-Mail lichaoqy@126.com

  

Article Information

Received: May 27, 2013
Accepted after revision: September 7, 2013
Published online: October 18, 2013
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 34

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 76, No. 4, Year 2013 (Cover Date: November 2013)

Journal Editor: D'Hooghe T.M. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 5/27/2013 10:27:57 AM
Accepted: 9/7/2013
Published online: 10/18/2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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