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Vol. 38, No. 1-2, 2014
Issue release date: July 2014
Section title: Original Research Article
Dement Geriatr Cogn Disord 2014;38:16-30
(DOI:10.1159/000355682)

Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention

Koscik R.L. · La Rue A. · Jonaitis E.M. · Okonkwo O.C. · Johnson S.C. · Bendlin B.B. · Hermann B.P. · Sager M.A.
aDepartment of Medicine, Wisconsin Alzheimer's Institute, bWisconsin Alzheimer's Disease Research Center, and cDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wis., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 9/13/2013
Published online: 2/20/2014

Number of Print Pages: 15
Number of Figures: 3
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Aim: It is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was to compare 3 psychometric methods of identifying amnestic mild cognitive impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. Methods: Wisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over approximately 6 years were coded as meeting each of 3 psychometric aMCI definitions: (a) ‘aMCI standard-baseline' used published norms to establish cutoffs for baseline performance; (b) ‘aMCI robust-baseline' applied WRAP-specific robust norms to baseline, and (c) ‘aMCI robust-multiwave' applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset. Results: Half the aMCI standard-baseline and one third of the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI × age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over 6 years of follow-up. Conclusion: Both cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts.


  

Author Contacts

Rebecca L. Koscik
Wisconsin Alzheimer's Institute
University of Wisconsin School of Medicine and Public Health
7818 Big Sky Drive, Suite 215, Madison, WI 53719 (USA)
E-Mail rekoscik@wisc.edu

  

Article Information

Accepted: September 13, 2013
Published online: February 20, 2014
Number of Print Pages : 15
Number of Figures : 3, Number of Tables : 2, Number of References : 56
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 38, No. 1-2, Year 2014 (Cover Date: July 2014)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 9/13/2013
Published online: 2/20/2014

Number of Print Pages: 15
Number of Figures: 3
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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