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Vol. 21, No. 2-3, 2014
Issue release date: February 2014
Section title:  
Neuroimmunomodulation 2014;21:79-87
(DOI:10.1159/000356529)

Innate Immune System and Inflammation in Alzheimer's Disease: From Pathogenesis to Treatment

Serpente M. · Bonsi R. · Scarpini E. · Galimberti D.
Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: 2/14/2014

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Immune activation and inflammation, likely triggered by amyloid-beta (Aβ) deposition, play a remarkable role in the pathogenesis of Alzheimer's disease (AD), which is the most frequent cause of dementia in the elderly. The principal cellular elements of the brain innate immune system likely to be involved in such processes are microglia. In an attempt to search for new disease-modifying drugs, the immune system has been addressed, with the aim of removing deposition of Aβ or tau by developing vaccines and humanized monoclonal antibodies. The aim of this review is to summarize the current evidence regarding the role played by microglia and inflammatory molecules in the pathogenesis of AD. In addition, we will discuss the main active and passive immunotherapeutic approaches.


  

Author Contacts

Maria Serpente
Neurology Unit, Department of Pathophysiology and Transplantation
University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico
Via Francesco Sforza 35, IT-20122 Milan (Italy)
E-Mail maria.serpente@unimi.it

  

Article Information

M.S. and R.B. contributed equally to this work.

Published online: February 14, 2014
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 0, Number of References : 71

  

Publication Details

Neuroimmunomodulation

Vol. 21, No. 2-3, Year 2014 (Cover Date: February 2014)

Journal Editor: Savino W. (Rio de Janeiro)
ISSN: 1021-7401 (Print), eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of  

Published online: 2/14/2014

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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