Sight-Threatening Ocular Manifestations of Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome)Baartman B. · Kosari P. · Warren C.C. · Ali S. · Jorizzo J.L. · Sato M. · Kurup S.K.
aDepartment of Ophthalmology, Wake Forest University Eye Center, and Departments of bDermatology and cPathology, Wake Forest University Baptist Medical Center, Winston-Salem, N.C., USA; dDepartment of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
Sweet's syndrome is a primarily dermatologic disorder with many features of systemic inflammation. It is generally characterized by a neutrophilic dermatosis in the setting of fever and an elevated white blood cell count. Inflammation has been described to occur in many organ systems including the lung, bone, liver, spleen, brain and eye. Ocular inflammation is a well-known comorbidity that may occur in the setting of Sweet's syndrome, including conjunctivitis, episcleritis, scleritis, iritis and choroiditis, among other forms. In the current article, we have compiled a series of cases that describe three separate patients who demonstrated a rare form of ocular involvement in Sweet's syndrome, retinal vasculitis. The evidence from these three cases and other reports in recent ophthalmologic literature suggest overlapping of ocular manifestations of Sweet's syndrome and the closely related Behçet's disease. It is important to be aware of the sometimes challenging differential between these two disorders and their sight-threatening complications.
Shree K. Kurup, MD
Department of Ophthalmology, Wake Forest University Eye Center
Medical Center Boulevard
Winston-Salem, NC 27157 (USA)
Received: March 4, 2013
Accepted after revision: December 2, 2013
Published online: March 1, 2014
Number of Print Pages : 5
Number of Figures : 6, Number of Tables : 0, Number of References : 13
Vol. 228, No. 3, Year 2014 (Cover Date: June 2014)
Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)
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