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Vol. 102, No. 3, 1999
Issue release date: January 2000
Section title: Original Paper
Acta Haematol 1999;102:152–156
(DOI:10.1159/000040991)

Are Haemochromatosis Mutations Related to the Severity of Liver Disease in Hepatitis C Virus Infection?

Martinelli A.L.C.a · Franco R.F.a,c · Villanova M.G.a · Figueiredo J.F.C.a · Secaf M.a · Tavella M.H.a · Ramalho L.N.Z.b · Zucoloto S.b · Zago M.A.a,c
aDepartment of Medicine and bDepartment of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, and cBlood Centre of Ribeirão Preto, FUNDHERP, São Paulo, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/17/2004
Issue release date: January 2000

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

It has been proposed that iron overload may adversely affect liver disease outcome. The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection. We investigated the prevalence of HFE mutations in 135 male patients with chronic HCV hepatitis, and correlated genotype distribution with different parameters of iron status and the activity and severity of liver disease. Of these 135 patients, 6 (4.4%) carried Cys282Tyr and 32 (23.7%) carried His63Asp, frequencies which were similar to those observed in healthy controls. Serum iron levels and transferrin saturation (but not ferritin levels or liver iron content) were significantly higher in carriers than in non-carriers of HFE mutations. No difference was observed in serum ALT, AST and GGT levels between carriers and non-carriers. Finally, scores for necroinflammatory activity and fibrosis in the liver were significantly higher in HFE carriers than in non-carriers. Patients with chronic HCV infection carrying HFE mutations tend to present more evident body iron accumulation and a higher degree of necroinflammatory activity and fibrosis in the liver. HFE gene mutations might be an additional factor to be considered among those implicated in the determination of a worse prognosis of the liver disease in chronic HCV infection.

© 2000 S. Karger AG, Basel


  

Author Contacts

Dr. A.L.C. Martinelli, MD, PhD
Department of Medicine, School of Medicine of Ribeirão Preto
University of São Paulo
14048–900-Ribeirão Preto-SP (Brazil)
Tel. +55 16 602 24 64, Fax +55 16 633 11 44, E-Mail adlcmart@fmrp.usp.br

  

Article Information

Received: Received: January 29, 1999
Accepted: August 5, 1999
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 27

  

Publication Details

Acta Haematologica
Founded 1948
Affiliated with Molecular Biology of Hematopoiesis Symposium

Vol. 102, No. 3, Year 1999 (Cover Date: Released January 2000)

Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/journals/aha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/17/2004
Issue release date: January 2000

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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