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Original Research

Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction

Ipek G.a · Onuk T.a · Karatas M.B.a · Güngör B.a · Atasoy I.a · Murat A.a · Aldag M.b · Yelgec N.S.a · Dayi S.U.a · Bolca O.a

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Departments of aCardiology and bCardiovascular Surgery, Siyami Ersek Cardiothoracic Surgery Center, Istanbul, Turkey

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Cardiology 2015;132:105-110

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: December 29, 2014
Accepted: May 11, 2015
Published online: June 27, 2015
Issue release date: September 2015

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: This study aimed to evaluate the relationship between the neutrophil-to-lymphocyte (N/L) ratio and left ventricular free wall rupture (LVFWR) in patients with ST elevation myocardial infarction (STEMI). Previous studies showed a correlation between increased levels of inflammatory markers and adverse cardiovascular events. The role of inflammation markers, particularly the N/L ratio, in mechanical complications after myocardial infarction has not been studied. Methods: Retrospectively, we compared the N/L ratio values of 23 patients with STEMI complicated by LVFWR with 214 STEMI patients without this complication. The diagnosis of rupture was confirmed by echocardiography in each case. Results: Neutrophil counts [median 8.5 × 103/µl, interquartile range (IQR) 6.4, vs. 7.8 × 103/µl, IQR 4.7, p = 0.02] and the N/L ratio (5.66, IQR 4.17, vs. 4.1, IQR 3.93, p = 0.01) were significantly higher in the LVFWR group. In receiver operating characteristic analysis, an N/L ratio above 3.7 predicted LVFWR with a sensitivity of 82.6% and a specificity of 46.9% (area under the curve = 0.654, p = 0.016). In multivariate regression analysis, age, hypertension, increased creatinine levels and increased N/L ratio (odds ratio = 1.61, 95% confidence interval = 1.15-2.23, p = 0.01) were found to be independent predictors of LVFWR. Conclusions: In our study, the N/L ratio was found to be independently correlated with the risk of LVFWR.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: December 29, 2014
Accepted: May 11, 2015
Published online: June 27, 2015
Issue release date: September 2015

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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