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Table of Contents
Vol. 68, No. 1, 2016
Issue release date: January 2016
Section title: Original Paper
Ann Nutr Metab 2016;68:1-11
(DOI:10.1159/000441481)

Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant

Platt D.E.i · Ghassibe-Sabbagh M.a · Salameh P.c · Salloum A.K.a · Haber M.a · Mouzaya F.a · Gauguier D.d, e · Al-Sarraj Y.f · El-Shanti H.f, g · Zalloua P.A.a, h · Abchee A.B.b
aLebanese American University, School of Medicine, and bAmerican University of Beirut, School of Medicine, Beirut, and cLebanese American University, School of Pharmacy, Byblos, Lebanon; dSorbonne Universities, University Pierre and Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERMUMR_S 1138, Cordeliers Research Centre, and eInstitute of Cardiometabolism and Nutrition, University Pierre and Marie Curie, Paris, France; fQatar Biomedical Research Institute, Doha, Qatar; gUniversity of Iowa Carver College of Medicine, Iowa City, hHarvard School of Public Health, Boston, Mass., and iBioinformatics and Pattern Discovery, IBM T.J. Watson Research Centre, Yorktown Heights, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 18, 2015
Accepted: September 29, 2015
Published online: November 21, 2015
Issue release date: January 2016

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Cultural, dietary, and lifestyle factors are the main modulators of type 2 diabetes mellitus (T2DM) disease risk. Coffee is one of the most popular worldwide beverages, and recent epidemiological studies have showed that coffee consumption is associated with a lower risk of T2DM. This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM. Data from 7,607 study subjects were analyzed by logistic regression models, among whom 3,290 GWAS data were available for CYP variants association studies using Plink analysis. These data suggest a protective relationship for women, but not for men; however, the results were not statistically significant in this dataset and there is a significant interaction in favor of women regarding heavy coffee consumption. The interaction between male gender and heavy coffee consumption becomes significant, thereby tending to cancel the protective effect of coffee for males. CYP rs2470890 allele ‘C' increases the odds of T2DM by a factor of around 1.2 but decreases the odds of caffeine boosting T2DM of 1.7 by a factor of 0.77. rs2470890 showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 18, 2015
Accepted: September 29, 2015
Published online: November 21, 2015
Issue release date: January 2016

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.