Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major α-heavy chain spots. However, the volume of the α-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 ± 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 ± 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.
Dr. O.H. Hashim
Department of Biochemistry
Faculty of Medicine, University of Malaya
50603 Kuala Lumpur (Malaysia)
Received: Accepted: September 15, 1997
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 19
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Vol. 78, No. 3, Year 1998 (Cover Date: March 1998)
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Article / Publication Details
Published online: 2/25/1998
Issue release date: March 1998
Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
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