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Vol. 83, No. 4, 1999
Issue release date: December 1999
Section title: Original Paper
Nephron 1999;83:331–340
(DOI:10.1159/000045425)

Metallothioneins in Human Kidneys and Associated Tumors

Hellemans G.a · Soumillion A.a · Proost P.b · van Damme J.b · van Poppel H.c · Baert L.c · De Ley M.a
aLaboratory for Biochemistry, Department of Chemistry, bLaboratory of Molecular Immunology, Rega Institute, and cDivision of Urology, Gasthuisberg University Hospital, Katholieke Universiteit Leuven, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/30/1999
Issue release date: December 1999

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 1

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Human kidneys and their associated tumors (nonneoplastic kidney tissues from patients with a transitional cell carcinoma or an adenocarcinoma and the adenocarcinomas themselves) were evaluated for their Zn, Cd, and Cu contents as well as for their metallothionein (MT) level. The total Cd content was correlated with the MT content, and both values were significantly decreased in the adenocarcinomas in comparison with the other tissues. After extraction and separation by anion-exchange chromatography, MT-0 was identified in the nonneoplastic tissues from both the adenocarcinomas as well as the transitional cell carcinomas. Since until now MT-0 protein was only found in human fetal liver and in Zn-stimulated human monocytes, a possible role for this isoform as an oncofetal marker is hypothesized. Separation of the isoforms of MT by reversed-phase high-performance liquid chromatography and sequence analysis showed besides MT-1e and MT-1l the isoform-MT-1g, which is not expressed in the healthy kidney, and MT-1k, an isoform which is not yet demonstrated in renal tissues. We conclude that the expression profile of the MT isoforms in the kidney changes due to the presence of a tumor.

© 1999 S. Karger AG, Basel


  

Author Contacts

Prof. Dr. M. De Ley
Laboratory for Biochemistry
Celestijnenlaan 200G
B–3001 Heverlee (Belgium)
Tel. +32 16 327 317, Fax +32 16 327 978, E-Mail Marc.DeLey@chem.kuleuven.ac.be

  

Article Information

Accepted:June 23, 1999
Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 1, Number of References : 29

  

Publication Details

Nephron
Founded 1964 by G. Richet and G.E. Schreiner

Vol. 83, No. 4, Year 1999 (Cover Date: December 1999)

Journal Editor: G.M. Berlyne, Brooklyn, N.Y./Beersheva; S. Ito, Sendai
ISSN: 0028–2766 (print), 1423–0186 (Online)

For additional information: http://www.karger.com/journals/nef


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/30/1999
Issue release date: December 1999

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 1

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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