Apolipoprotein E Polymorphism in IgA NephropathyYorioka N. · Nishida Y. · Oda H. · Watanabe T. · Yamakido M.
2nd Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
Background/Aim: To clarify the role of the apolipoprotein E (Apo E) phenotype in IgA nephropathy, we investigated its relationship with histological damage and clinical factors. Methods: The subjects were 104 consecutive patients (41 men and 63 women) with IgA nephropathy. The Apo E phenotype was identified by plasma isoelectric focusing and immunoblotting, and the frequencies of Apo E alleles were calculated. Results: The frequencies of the phenotypes and the alleles were as follows: 2/2 = 0, 2/3 = 0.086, 3/3 = 0.654, 2/4 = 0.010, 4/3 = 0.211, 4/4 = 0.010, 3/5 = 0.029, ε2 = 0.048, ε3 = 0.817, ε4 = 0.120, and others = 0.015. There were no significant differences between the IgA nephropathy patients and healthy individuals in the frequencies of Apo E phenotypes and the alleles. However, the Apo E2 phenotype was significantly more common among patients with severe histological damage than in those with mild damage. The serum triglyceride levels were significantly elevated, and the Apo E2 phenotype was significantly more prevalent in patients with severe histological damage as compared with those with mild damage. Conclusion: The Apo E2 phenotype appears to be associated with the severity of histological damage in IgA nephropathy.
Dr. N. Yorioka
2nd Department of Internal Medicine, Hiroshima University School of Medicine
1-2-3 Kasumi Minami-ku
Hiroshima 734-8551 (Japan)
Tel. +81 82 257 5196, Fax +81 82 255 7360
Received: Accepted: June 17, 1999
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 3, Number of References : 19
Founded 1964 by G. Richet and G.E. Schreiner
Vol. 83, No. 3, Year 1999 (Cover Date: November 1999)
Journal Editor: G.M. Berlyne, Brooklyn, N.Y./Beersheva; S. Ito, Sendai
ISSN: 0028–2766 (print), 1423–0186 (Online)
For additional information: http://www.karger.com/journals/nef