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Vol. 170, No. 2-3, 2002
Issue release date: 2002
Section title: Original Paper
Cells Tissues Organs 2002;170:132–138
(DOI:10.1159/000046186)

Sieve Plugs in Fenestrae of Glomerular Capillaries – Site of the Filtration Barrier?

Rostgaard J. · Qvortrup K.
Department of Medical Anatomy Section B, University of Copenhagen, The Panum Institute, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/5/2001
Issue release date: 2002

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

The exact location of the filtration barrier of the glomerular capillary wall, which consists of an endothelium, a basement membrane and a visceral epithelium, has not yet been determined. Apparent discrepancies between different investigators in the past could be explained if postmortem artifactual tissue changes, due to subnormal blood pressure or anoxia, have taken place in the endothelium before the tissue and tracers have been sufficiently fixed and immobilized by the fixative. To test this supposition, a new method of fixation, which includes a technique to maintain a physiological perfusion pressure and a fixative composed of an oxygen-carrying blood substitute fluid containing glutaraldehyde, was employed combined with contrast enhancement. New observations of the glomerular capillary wall revealed that filamentous plugs (about 90 nm in height) filled the capillary fenestrae and a filamentous surface coat about 60 nm thick covered the interfenestral domains of the endothelial cell. Based on these purely morphological data, we dare to suggest that the fenestral plugs are the primary site of the glomerular filtration barrier – albeit highly speculative, nevertheless a logical location – and consequently that the glomerular filtration process is a ‘tangential-flow’ as opposed to a ‘dead-end’ filtration process. A tangential-flow filtration would minimize ‘clogging’ and ‘concentration polarization’ in the ‘filter’.

© 2002 S. Karger AG, Basel


  

Author Contacts

K. Qvortrup, MD, PhD
Department of Medical Anatomy Section B
University of Copenhagen, The Panum Institute
3 Blegdamsvej, DK–2200 N (Denmark)
Tel. +45 3532 7251, Fax +45 3566 9612, E-Mail K.Qvortrup@mai.ku.dk

  

Article Information

Received: Accepted after revision: April 25, 2001
Number of Print Pages : 7
Number of Figures : 5, Number of Tables : 0, Number of References : 31

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)
Founded 1945 as Acta Anatomica

Vol. 170, No. 2-3, Year 2002 (Cover Date: 2002)

Formerly Acta Anatomica

Journal Editor: H.-W. Denker, Essen; A.W. English, Atlanta, Ga.
ISSN: 1422–6405 (print), 1422–6421 (Online)

For additional information: http://www.karger.com/journals/cto


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/5/2001
Issue release date: 2002

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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