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Vol. 104, No. 4, 2000
Issue release date: March 2001
Section title: Original Paper
Acta Haematol 2000;104:151–157
(DOI:10.1159/000046507)

Cellular Distribution of Platelet-Derived Growth Factor, Transforming Growth Factor-β, Basic Fibroblast Growth Factor, and Their Receptors in Normal Bone Marrow

Yoon S.-Y.b · Tefferi A.a · Li C.-Y.b
Divisions of aHematology and Internal Medicine and bHematopathology, Mayo Clinic and Mayo Foundation, Rochester, Minn., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/22/2001
Issue release date: March 2001

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2–3, and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.

© 2001 S. Karger AG, Basel


  

Author Contacts

Chin-Yang Li, MD
Division of Hematopathology, Mayo Clinic
200 First Street, SW
Rochester, MN 55905 (USA)
E-Mail li.chinyang@mayo.edu

  

Article Information

Dr. Yoon is a visiting Clinician at the Division of Hematopathology, from Clinical Pathology, Korea University, Seoul, Korea.

Received: Received: April 10, 2000
Accepted: August 18, 2000
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 52

  

Publication Details

Acta Haematologica
Founded 1948
Affiliated with Molecular Biology of Hematopoiesis Symposium

Vol. 104, No. 4, Year 2000 (Cover Date: Released March 2001)

Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/journals/aha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/22/2001
Issue release date: March 2001

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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