Update on Tumor Cell Procoagulant FactorsGale A.J. · Gordon S.G.
aDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif., and bDepartment of Biology, San Diego State University, San Diego, Calif., USA
Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, vascular wall function, and hemostasis. Proteases and their inhibitors are intimately involved in all aspects of the hemostatic, cell proliferation and cellular signalling systems. This review provides a brief examination of recent observations in this complex interaction of cellular and hemostatic factors.
Stuart G. Gordon, PhD
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Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 0, Number of References : 81
Affiliated with Molecular Biology of Hematopoiesis Symposium
Vol. 106, No. 1-2, Year 2001 (Cover Date: Released September 2001)
Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)
For additional information: http://www.karger.com/journals/aha