Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, vascular wall function, and hemostasis. Proteases and their inhibitors are intimately involved in all aspects of the hemostatic, cell proliferation and cellular signalling systems. This review provides a brief examination of recent observations in this complex interaction of cellular and hemostatic factors.
© 2001 S. Karger AG, Basel
Stuart G. Gordon, PhD
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Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 0, Number of References : 81
Affiliated with Molecular Biology of Hematopoiesis Symposium
Vol. 106, No. 1-2, Year 2001 (Cover Date: Released September 2001)
Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)
For additional information: http://www.karger.com/journals/aha
Article / Publication Details
Published online: 9/12/2001
Issue release date: September 2001
Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: http://www.karger.com/AHA
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