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Vol. 45, No. 4, 2001
Issue release date: July–August 2001
Section title: Original Paper
Ann Nutr Metab 2001;45:135–142
(DOI:10.1159/000046720)

A Case-Control Study of the Effect of Infant Feeding on Celiac Disease

Peters U. · Schneeweiss S. · Trautwein E.A. · Erbersdobler H.F.
aInstitute of Human Nutrition and Food Science, University of Kiel, Germany; bDepartment of Epidemiology, Harvard School of Public Health, Boston, Mass., USA; and cDepartment of Medical Informatics, Biometry and Epidemiology, University of Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/18/2001

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Aims: The aim of this study was to investigate the association between the duration of breast-feeding and the age at the first gluten introduction into the infant diet and the incidence and age at onset of celiac disease. Methods: In a case-control study, 143 children with celiac disease and 137 randomly recruited gender- and age-matched control children were administered a standardized questionnaire. Multivariate-adjusted odds ratios (OR) as estimates of the relative risk and corresponding 95% confidence intervals (95% CI) were calculated. Results: The risk of developing celiac disease decreased significantly by 63% for children breast-fed for more than 2 months (OR 0.37, 95% CI 0.21–0.64) as compared with children breast-fed for 2 months or less. The age at first gluten introduction had no significant influence on the incidence of celiac disease (OR 0.72, 95% CI 0.29–1.79 comparing first gluten introduction into infant diet >3 months vs. ≤3 months). Conclusions: A significant protective effect on the incidence of celiac disease was suggested by the duration of breast-feeding (partial breast-feeding as well as exclusive breast-feeding). The data did not support an influence of the age at first dietary gluten exposure on the incidence of celiac disease. However, the age at first gluten exposure appeared to affect the age at onset of symptoms.


  

Author Contacts

Prof. Helmut F. Erbersdobler
University of Kiel, Institute of Human Nutrition and Food Science
Düsternbrooker Weg 17, D–24105 Kiel (Germany)
Tel. +49 431 597 36780, Fax +49 431 597 3679
E-Mail erbersdobler@nutrfoodsc.uni-kiel.de

  

Article Information

U.P. is currently working at the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Md., USA, and S.S. is currently working at the Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass., USA.

Received: Received: May 4, 2000
Accepted: December 27, 2000
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 4, Number of References : 34

  

Publication Details

Annals of Nutrition & Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)
Founded 1959 as ’Nutritio et Dieta‘ by E. Azerad, H. Kapp and J. Trémolières
Official Journal of the Federation of European Nutrition Societies (FENS)

Vol. 45, No. 4, Year 2001 (Cover Date: July-August 2001)

Journal Editor: G. Wolfram, Freising
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/journals/anm


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/18/2001

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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