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Vol. 20, No. 2, 2002
Issue release date: 2002
Section title: Original Paper
Blood Purif 2002;20:161–166
(DOI:10.1159/000047003)

Membrane Flux Not Biocompatibility Determines Beta-2-Microglobulin Levels in Hemodialysis Patients

Pickett T.M.a · Cruickshank A.b · Greenwood R.N.b · Taube D.c · Davenport A.d · Farrington K.b
aDirectorate of Medicine, Gloucestershire Royal Hospital, Gloucester; bRenal Unit, Lister Hospital, Stevenage; cRenal and Transplant Unit, St Mary’s Hospital, London, and dCentre for Nephrology, Royal Free Hospital, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/30/2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Background: Serum β2-microglobulin (β2M) levels are important in dialysis-related amyloid deposition but can be influenced by dialysis technique. Methods: We measured β2M levels in 3 centres using different dialysis regimes. Centre 1 (73 patients) used high-flux biocompatible, centre 2 (72 patients) low-flux biocompatible and centre 3 (142 patients) cuprophane dialysers. Results: β2M levels were lower with high-flux biocompatible than with low-flux biocompatible or cuprophane dialysis (22.3 ± 5.4 vs. 43.4 ±13.7 and 37.6 ±13.1 mg/l, respectively; p < 0.001). Levels were higher with low-flux biocompatible than with cuprophane dialysis (p < 0.001), but not if patients dialysed over 10 years were excluded. With low-flux biocompatible (47.4 ± 9.8 vs. 38.7 ± 15.2 mg/l; p < 0.01) and cuprophane dialysis (43.4 ± 8.2 vs. 36.7 ± 13.0 mg/l; p < 0.02), β2M levels were higher in patients dialysed over 5 years than in those dialysed less. Despite β2M levels increasing as residual renal function declined, there was no similar rise with high-flux biocompatible dialysis. Conclusions: Techniques allowing significant convection maintain lower β2M levels over many years. Membrane flux, not biocompatibility, is the main determinant of β2M levels in routine practice.

© 2002 S. Karger AG, Basel


  

Author Contacts

Dr. Ken Farrington
Renal Unit
Lister Hospital
Stevenage, Herts SG1 4AB (UK)
Fax +44 1438 781174, E-Mail KenFarring@aol.com

  

Article Information

Accepted: August 6, 2001.
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 31

  

Publication Details

Blood Purification (Official Journal of the International Society of Blood Purification (ISBP))
Founded 1983; edited by K. Schaefer (1983–1988)
Official Journal of the International Society of Blood Purification

Vol. 20, No. 2, Year 2002 (Cover Date: 2002)

Journal Editor: L.W. Henderson, McGaw Park, Ill.
ISSN: 0253–5068 (print), 1421–9735 (Online)

For additional information: http://www.karger.com/journals/bpu


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/30/2002
Issue release date: 2002

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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