The purpose was to discover whether fluoride (F) accumulates in the aged human pineal gland. The aims were to determine (a) F–concentrations of the pineal gland (wet), corresponding muscle (wet) and bone (ash); (b) calcium–concentration of the pineal. Pineal, muscle and bone were dissected from 11 aged cadavers and assayed for F using the HMDS–facilitated diffusion, F–ion–specific electrode method. Pineal calcium was determined using atomic absorption spectroscopy. Pineal and muscle contained 297±257 and 0.5±0.4 mg F/kg wet weight, respectively; bone contained 2,037±1,095 mg F/kg ash weight. The pineal contained 16,000±11,070 mg Ca/kg wet weight. There was a positive correlation between pineal F and pineal Ca (r = 0.73, p<0.02) but no correlation between pineal F and bone F. By old age, the pineal gland has readily accumulated F and its F/Ca ratio is higher than bone.
Department of Obstetrics and Gynaecology, Holland wing, The Royal London Hospital
Whitechapel Road, London E1 1BB (UK)
Tel. +44 207 377 7000 ext. 3146, Fax +44 1342 826166
Received: Received: September 14, 1999
Accepted after revision: August 10, 2000
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 32
Caries Research (Journal of the European Organization for Caries Research (ORCA))
Journal founded 1967 by Y. Ericsson; edited 1970–1987 by K.G. König; 1987–1994 by J.M. ten Cate; 1994–2000 by J. Tenovuo
Vol. 35, No. 2, Year 2001 (Cover Date: March-April 2001)
Journal Editor: R.P. Shellis, Bristol
ISSN: 0008–6568 (print), 1421–976X (Online)
For additional information: http://www.karger.com/journals/cre
Article / Publication Details
Published online: 3/9/2001
Issue release date: March–April 2001
Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0
ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)
For additional information: http://www.karger.com/CRE
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