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Table of Contents
Vol. 11, No. 3, 2001
Issue release date: April 2001
Section title: Original Paper
Cerebrovasc Dis 2001;11:216–224
(DOI:10.1159/000047642)

Prestroke Dementia

Barba R.a · Castro M.D.b · del Mar Morín M.b · Rodriguez-Romero R.c · Rodríguez-García E.b · Cantón R.b · Del Ser T.b
aServicio de Medicina Interna, Hospital de Alcorcón, Madrid, bSección de Neurología, Hospital Severo Ochoa, Leganés, Madrid, cServicio de Radiología, Hospital Virgen del Rocio, Sevilla, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 06, 2001
Issue release date: April 2001

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Objective: To determine the frequency, associated factors and outcome of dementia previous to a stroke. Design: Cross-sectional study of a cohort of 324 consecutive unselected stroke patients (mean age 70.9 years, range 20–98; 255 ischaemic, 46 haemorrhagic and 25 indefinite). Methods: Cognitive and functional status prior to stroke were assessed by means of an interview to a relative, a short version of the Informant Questionnaire on Cognitive Decline in the Elderly and the Barthel Index. The DSM-III-R criteria were used to establish the diagnosis of prestroke dementia. Clinical and CT features of patients with and without prestroke dementia were compared. Results: Forty-nine patients (15%) were demented before stroke; they were significantly older, less well educated, they had more frequently female gender, prior cerebrovascular disease, cerebral and medial temporal lobe atrophy and leukoaraiosis in the CT scan, and they had a higher mortality rate. Female sex (OR 3.7, CI 95% 1.2–12), low education (OR 2.1, CI 95% 1.1–4.2), previous stroke (OR 3.6, CI 95% 1.2–11), and cerebral atrophy (OR 3.8, CI 95% 1.7–8.3) were independently associated with prestroke dementia in the logistic regression analysis. Conclusions: Fifteen percent of stroke patients have prestroke dementia and they have a worse outcome. Factors associated with prestroke dementia are reminiscent both of degenerative and vascular brain pathology.

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 06, 2001
Issue release date: April 2001

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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