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Table of Contents
Vol. 169, No. 3, 2001
Issue release date: 2001
Section title: Paper
Cells Tissues Organs 2001;169:238–247
(DOI:10.1159/000047887)

Orofacial Deep and Cutaneous Tissue Inflammation and Trigeminal Neuronal Activation

Implications for Persistent Temporomandibular Pain

Imbe H. · Iwata K. · Zhou Q.-Q. · Zou S. · Dubner R. · Ren K.
aDepartment of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, Md., USA; bDepartment of Oral Physiology, Faculty of Dentistry, Osaka University, Osaka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/29/2001

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

A rat model has been developed to characterize the responses of brainstem trigeminal neurons to orofacial deep and cutaneous tissue inflammation and hyperalgesia. Complete Freund’s adjuvant (CFA) was injected unilaterally into the rat temporomandibular joint (TMJ) or perioral (PO) skin to produce inflammation in deep or cutaneous tissues, respectively. The TMJ and PO inflammation resulted in orofacial behavioral hyperalgesia and allodynia that peaked within 4–24 h and persisted for at least 2 weeks. Compared to cutaneous CFA injection, the injection of CFA into the TMJ produced a significantly stronger inflammation associated with a selective upregulation of preprodynorphin mRNA in the trigeminal spinal complex, an enhanced medullary dorsal horn hyperexcitability, and a greater trigeminal Fos protein expression, a marker of neuronal activation. The Fos-LI induced by TMJ inflammation persisted longer, was more intense, particularly in the superficial laminae, and more widespread rostrocaudally. Thus, the inflammatory irritant produces a stronger effect in deep than in cutaneous orofacial tissue. As there is heavy innervation of the TMJ by unmyelinated nerve endings, a strong nociceptive primary afferent barrage is expected following inflammation. An increase in TMJ C-fiber input after inflammation and strong central neuronal activation may initiate central hyperexcitability and contribute to persistent pain associated with temporomandibular disorders. Since deep inputs may be more effective in inducing central neuronal excitation than cutaneous inputs, greater sensory disturbances may occur in pain conditions involving deep tissues than in those involving cutaneous tissues.


  

Author Contacts

K. Ren, PhD
Department of OCBS
666 W, Baltimore St., Rm. 5A12
Baltimore, MD 21201 (USA)
Tel. +1 410 706 3250, Fax +1 410 706 4172, E-Mail kren@umaryland.edu

  

Article Information

Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 0, Number of References : 64

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)
Founded 1945 as Acta Anatomica

Vol. 169, No. 3, Year 2001 (Cover Date: 2001)

Formerly Acta Anatomica

Journal Editor: H.-W. Denker, Essen; A.W. English, Atlanta, Ga.
ISSN: 1422–6405 (print), 1422–6421 (Online)

For additional information: http://www.karger.com/journals/cto


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/29/2001

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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